Efficacy of Platelet Rich Plasma (PRP) on Mouth Opening and Pain After Surgical Extraction of Mandibular Third Molars.

Not Applicable

Completed

• Conditions: Tooth Extraction
• Interventions: Procedure: Surgical Extraction; Procedure: Platelet Rich Plasma (PRP)

• Registration Number: NCT04452734
• Lead Sponsor: Foundation University Islamabad

Brief Summary

Wisdom tooth extraction is the most common surgical procedure being carried out in oral surgical departments. The complications carried by post operative period include pain and trismus and may affect patient's quality of life.

PRP is an autologous concentrate of platelet in plasma and accelerate healing by production of growth factors. PRP is prepared from patient's own blood and later packed with gel sponge (Spongistone) in the experimental group immediately after surgical extraction of mandibular third molar teeth, followed by suture placement to close the surgical site.

Detailed Description

Wisdom tooth extraction is the most common surgical procedure being carried out in oral surgical departments. The complications carried by post operative period includes pain, swelling, trismus , along with disturbance in post extraction wound healing which may significantly affect patient's quality of life.

PRP is an autologous concentrate of platelet suspended in plasma and accelerate healing by production of various growth factors. PRP is prepared from patient's own blood and later packed with gel sponge (Spongistone) in the experimental group immediately after surgical extraction of mandibular third molar teeth, followed by suture placement to close the surgical site. PRP speeds up healing by concentration of growth factors which can lessen the inflammation and decreases trismus and pain.

Study Timeline

• Study Start: 2015-07-21
• Primary Completion: 2016-05-14
• Study Completion: 2016-05-14
• Status Verified: 2020-04
• Study First Submitted: 2020-04-06
• Study First Submitted QC: 2020-06-29
• Last Update Submitted: 2020-06-29
• Study First Posted: 2020-06-30
• Last Update Posted: 2020-06-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

1. Age between 18-45 iyears
2. Either gender
3. Patients requiring extraction of mandibular 3rd molars
4. ASA grade1
5. Nonsmokers & non alcoholics
6. Not allergic to any medicines
7. No pain before the extraction procedure
8. No trismus, i.e. normal mouth opening before the extraction procedure -

Exclusion Criteria

a) Systemic diseases b) Compromised immune system c) Platelet count less than 1.5 lacs/cmm d) Allergy to drugs e) Patients not willing to participate in the study f) Pregnant females/Lactating mothers g) Presence of pericoronitis, periapical infection or any associated lesion.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control Group	Surgical Extraction	-
Study Group	Surgical Extraction	-
Study Group	Platelet Rich Plasma (PRP)	-

Primary Outcome Measures

Name	Time	Method
Trismus	7th post op day	Trismus was quantified/measured using Vernier Calliper.
Visual Analogue Scale (VAS)	7th post op day	Visual Analogue Scale (VAS) used to quantify pain