Efficacy of Platelet Rich Plasma (PRP) on Mouth Opening and Pain After Surgical Extraction of Mandibular Third Molars.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Tooth Extraction
- Sponsor
- Foundation University Islamabad
- Enrollment
- 130
- Primary Endpoint
- Trismus
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Wisdom tooth extraction is the most common surgical procedure being carried out in oral surgical departments. The complications carried by post operative period include pain and trismus and may affect patient's quality of life.
PRP is an autologous concentrate of platelet in plasma and accelerate healing by production of growth factors. PRP is prepared from patient's own blood and later packed with gel sponge (Spongistone) in the experimental group immediately after surgical extraction of mandibular third molar teeth, followed by suture placement to close the surgical site.
Detailed Description
Wisdom tooth extraction is the most common surgical procedure being carried out in oral surgical departments. The complications carried by post operative period includes pain, swelling, trismus , along with disturbance in post extraction wound healing which may significantly affect patient's quality of life. PRP is an autologous concentrate of platelet suspended in plasma and accelerate healing by production of various growth factors. PRP is prepared from patient's own blood and later packed with gel sponge (Spongistone) in the experimental group immediately after surgical extraction of mandibular third molar teeth, followed by suture placement to close the surgical site. PRP speeds up healing by concentration of growth factors which can lessen the inflammation and decreases trismus and pain.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age between 18-45 iyears
- •Either gender
- •Patients requiring extraction of mandibular 3rd molars
- •Nonsmokers \& non alcoholics
- •Not allergic to any medicines
- •No pain before the extraction procedure
- •No trismus, i.e. normal mouth opening before the extraction procedure -
Exclusion Criteria
- •a) Systemic diseases b) Compromised immune system c) Platelet count less than 1.5 lacs/cmm d) Allergy to drugs e) Patients not willing to participate in the study f) Pregnant females/Lactating mothers g) Presence of pericoronitis, periapical infection or any associated lesion.
Outcomes
Primary Outcomes
Trismus
Time Frame: 7th post op day
Trismus was quantified/measured using Vernier Calliper.
Visual Analogue Scale (VAS)
Time Frame: 7th post op day
Visual Analogue Scale (VAS) used to quantify pain