Efficacy of Platelet Rich Plasma (PRP) on Mouth Opening and Pain After Surgical Extraction of Mandibular Third Molars.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 130
- 主要终点
- Trismus
研究概览
简要总结
Wisdom tooth extraction is the most common surgical procedure being carried out in oral surgical departments. The complications carried by post operative period include pain and trismus and may affect patient's quality of life.
PRP is an autologous concentrate of platelet in plasma and accelerate healing by production of growth factors. PRP is prepared from patient's own blood and later packed with gel sponge (Spongistone) in the experimental group immediately after surgical extraction of mandibular third molar teeth, followed by suture placement to close the surgical site.
详细描述
Wisdom tooth extraction is the most common surgical procedure being carried out in oral surgical departments. The complications carried by post operative period includes pain, swelling, trismus , along with disturbance in post extraction wound healing which may significantly affect patient's quality of life.
PRP is an autologous concentrate of platelet suspended in plasma and accelerate healing by production of various growth factors. PRP is prepared from patient's own blood and later packed with gel sponge (Spongistone) in the experimental group immediately after surgical extraction of mandibular third molar teeth, followed by suture placement to close the surgical site. PRP speeds up healing by concentration of growth factors which can lessen the inflammation and decreases trismus and pain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18-45 iyears
- •Either gender
- •Patients requiring extraction of mandibular 3rd molars
- •Nonsmokers & non alcoholics
- •Not allergic to any medicines
- •No pain before the extraction procedure
- •No trismus, i.e. normal mouth opening before the extraction procedure -
排除标准
- •a) Systemic diseases b) Compromised immune system c) Platelet count less than 1.5 lacs/cmm d) Allergy to drugs e) Patients not willing to participate in the study f) Pregnant females/Lactating mothers g) Presence of pericoronitis, periapical infection or any associated lesion.
研究组 & 干预措施
Control Group
干预措施: Surgical Extraction (Procedure)
Study Group
干预措施: Platelet Rich Plasma (PRP) (Procedure)
Study Group
干预措施: Surgical Extraction (Procedure)
结局指标
主要结局
Trismus
时间窗: 7th post op day
Trismus was quantified/measured using Vernier Calliper.
Visual Analogue Scale (VAS)
时间窗: 7th post op day
Visual Analogue Scale (VAS) used to quantify pain
Visual Analogue Scale (VAS)
时间窗: 1 day
Visual Analogue Scale (VAS) used to quantify pain
Visual Analogue Scale (VAS)
时间窗: 3rd post op day
Visual Analogue Scale (VAS) used to quantify pain
Trismus
时间窗: 1 day
Trismus was quantified/measured using Vernier Calliper.
Trismus
时间窗: 3rd post op day
Trismus was quantified/measured using Vernier Calliper.
次要结局
未报告次要终点