CTRI/2025/12/099730尚未招募4 期
A prospective randomized controlled study to assess the Effect of Intravenous Injection of Magnesium Sulphate 30 mg per kg on Intraoperative End-Tidal Carbon Dioxide Level and Postoperative Pain in patients undergoing Laparoscopic Cholecystectomy
Pacific Medical College and Hospital Udaipur1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2026年1月10日最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
研究概览
简要总结
Laparoscopic cholecystectomy often causes increased EtCO2 due to pneumoperitoneum, leading to physiological stress and higher anaesthetic requirements. Magnesium sulphate, through its NMDA-antagonist and analgesic properties, has been shown to reduce sympathetic response, stabilise haemodynamics, and improve postoperative pain control. Although magnesium is widely used as an adjuvant in anaesthesia, its effect on intraoperative EtCO2 levels during laparoscopic surgery has not been clearly established. Hence, further evaluation is justified.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Adult patients of both genders aged between 18 to 65 years Patients Scheduled for elective laparoscopic cholecystectomy under general anesthesia American Society of Anesthesiologists physical status I or II Patients who provide written informed consent.
排除标准
- •Age 18 and 65 years Patient not giving written consent for study participation.
- •ASA physical status III and IV Known allergy or hypersensitivity to magnesium sulfate History of renal impairment or dysfunction eg creatinine clearance less than 60 ml per min Patients with cardiac conduction abnormalities eg heart block Patients on calcium channel blockers or magnesium-containing medications Severe hepatic dysfunction.
研究者
Dr Bharat Purohit
Pacific Medical College and Hospital
研究点 (1)
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