The impact of dietary cholesterol and the gut microbiota on the intestinal lipid resorption and the systemic lipid metabolism

Not Applicable

Suspended

• Conditions: E66; E78; K63; Obesity; Disorders of lipoprotein metabolism and other lipidaemias; Other diseases of intestine

• Registration Number: DRKS00020788
• Lead Sponsor: Technische Universität München, Wissenschaftszentrum Weihenstephan, Lehrstuhl für Molekulare Ernährungsmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-02-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Suspended
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Age 20 to 40
written consent
Europeans
BMI 18-35 kg/m²
Women and Men (1:1)

Exclusion Criteria

Missing written consent

active smokers

chronic diseases like:
chronic infection (e.g. HIV)
diagnosed liver diseases (e.g. HBV,HCV)
diagnosed diabetes mellitus
required to undergo dialysis

pregnant or breastfeeding women

active participation in other interventionstudies

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood:<br>Analysis of lipid species and bile acids by mass spectrometry.<br>Analysis of feces:<br>Analysis of bacterial communities by 16S rRNA sequencing. Analysis of bile acids by mass spectrometry. Collection of clinical chemistry parameters relevant to lipid metabolism.<br>By combining these data, we try to find a correlation between different microbiota species and blood lipid parameters and bile acids in relation to dietary cholesterol.<br>

Secondary Outcome Measures

Name	Time	Method
The generated Data are merged to find a correlation between microbiota and the cholesterol load as single aim, therefore a secondary outcome cannot be defined in this case.