A combined study 0f combined effectiveness, Lodhradi Kashaya And Navaka Guggulu in patients with Madumeha (Type 2 Diabetes Mellitus)

Phase 2/3

Not yet recruiting

• Conditions: Type 2 diabetes mellitus without complications. Ayurveda Condition: MADHUMEHAH/KSHAUDRAMEHAH,

• Registration Number: CTRI/2023/08/056755
• Lead Sponsor: Sri Dharmasthala Manjunatheswara College of Ayurveda and

Brief Summary

In this present generation the sedentary life style, lack of exercise, stress, life style modifications, change in dietary habits, urbanization precipitate the disease of *Santarpanjanya vyadhis* like as *Prameha 1*. It told as one of the *astamahaagadas 2, Madhumeha* is a *Vataja Prameha 3 .Prameha* is characterized by *Prabhutha mutratva* and *Avila mutratva* 4 The clinical feature like Madhura *asyata , karapadadaha, suptata, mukha talu kanthashosha, pipasa-adhikya, alasya, tandra 5* can be correlated to the features ofType 2 Diabetes Mellitus.Diabetes Mellitus Type 2 and its complications pose a major threat to public health resource throughout the world. In today’s era, Type 2 Diabetes Mellitus has gained gigantic disgrace in recent times as it is fast becoming the world’s largest silent killer. In 2021, Approximately 537 million adults (20-79 years) are living with Type 2 Diabetes Mellitus.The total number of people living with diabetes Type 2 is projected to rise to 643 million by 2030 and 783 million by 20456. It has become utmost importance to find ways to combat this disease. Adults with Type 2 Diabetes Mellitus have a two-threefold increased risk of heart attacks and strokes. Diabetes is the cause of 2.6% of global blindness and it’s also a leading causes of kidney failure 7.

 With an increasing incidence worldwide and due to chronic complications, there is need for effective management of Type 2 Diabetes mellitus. Ingredients of *Lodhradi Kashaya* possess *tikta kashaya rasa, laghu guna, katu vipaka,pramehagna karma* and *Navaka guggulu* possess *katu tikta rasa, laghu ,rooksha guna,kapha vatahara, medohara ,amapachana karma.* As *madumeha* is *santarparnajanya vyadhi*. *K**aph*a and *vata* is main dosha and *meda* is main *dushya* involved in the manifestation of *vyadhi*. These formulations may help to act against it. The ingredients of both formulations are safe and easily available. This study is intended to evaluate the effectiveness of this combination in *madhumeha* .

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-08-18
• Study Start: 2023-08-31

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• 1.Subjects above 30 years up to 70 years of either gender suffering from Type 2 Diabetes Mellitus under control will be taken.
• 2.Fasting blood sugar ≥ 126 mg/dL.
• 3.Post prandial blood sugar (PPBS) level ≥180 mg/dL.
• 4.Those patients willing to participate in the study and who are ready to sign the informed.

Exclusion Criteria

1.Subjects of Type 2 Diabetes Mellitus on insulin 2.Subjects of Type 2 Diabetes Mellitus with HbA1c >10%, FBS >250 mg/dl, PPBS >350mg/dl 3.Subjects with known case of cardiac illness, impaired kidney and liver function 4.Pregnant women and lactating mother.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
polydipsia	30
karapada daha	30
karapada suptata	30
polyurea	30
polyphagaia	30
angasaada	30

Secondary Outcome Measures

Name	Time	Method
Fasting blood glucose & Post prandial blood glucose- Before & after treatment (1st day & 31st day)	30 days

Trial Locations

Locations (1)

Sri Dharmasthala Manjunatheswara College Of Ayurveda And Hospital; 🇮🇳 Hassan, KARNATAKA, India

Sri Dharmasthala Manjunatheswara College Of Ayurveda And Hospital

🇮🇳Hassan, KARNATAKA, India

DR SHREYA M BANGRE

Principal investigator

7204780880

anumyd1993@gmail.com