nderstanding the role of acute exercise in modifying eosinophilic airway inflammation in asthma

Not Applicable

Completed

• Conditions: Asthma; Respiratory - Asthma

• Registration Number: ACTRN12615000294550
• Lead Sponsor: Dr Hayley Scott

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-03-27
• Study Completion: 2016-06-23
• Last Update Posted: 27 December 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

1.Physician diagnosed asthma
2.Able to provide written informed consent
3.Females 18-55 years of age or males 18-45 years of age
4.Body mass index (BMI) <=40kg/m2
5.Not a current smoker (never smoker or quit at least 6 months ago)
6.Post-bronchodilator forced expiratory volume in 1 second (FEV1) >=50% predicted.
7.Approved for vigorous exercise by the study coordinator, according to the ESSA Adult Pre-Exercise Screening Tool”.

Exclusion Criteria

1.Asthma is not the primary respiratory diagnosis
2.A moderate exacerbation (oral corticosteroid or antibiotic use) in the past four weeks or severe exacerbation (hospitalisation) in the past three months
3.Participation in a moderate-vigorous intensity exercise session within 2 days of the scheduled study visit.
4.Known cardiac condition
5.Musculoskeletal contraindication to exercise
6.Uncontrolled hypertension (blood pressure >180/100mmHg)
7.Cancer
8.Diabetes mellitus
9.Thyroid disorder
10.Taking cholesterol lowering medication or ß-blocker medication
11.Pregnancy or breastfeeding
12.Resting SpO2 <=95% on room air
13.Participation in an interventional research study in the last four weeks
14.Currently exercising at a moderate-intensity or greater for >90 mins/week
15.Subject has a clinically important medical illness (including serious psychological disorders) likely to interfere with management or participation in the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified