An Integrated Treatment for Comorbid PTSD and Substance Abuse in Adolescents

Not Applicable

Completed

• Conditions: Substance Abuse; Traumatic Stress
• Interventions: Behavioral: Trauma-focused Substance Abuse Intervention

• Registration Number: NCT01825694
• Lead Sponsor: University of California, Los Angeles

Brief Summary

This study plans to develop an integrated treatment for comorbid post-traumatic stress disorder (PTSD) and substance abuse (SA) in adolescents. The investigators aim to develop a treatment approach that is community-friendly, well-tolerated, and deliverable by substance abuse counselors (SAC) in outpatient settings. The proposed Trauma-Focused Substance Abuse Treatment (TFSAT) aims to reduce PTSD symptoms and substance use and build coping skills. The investigators propose to adapt an evidence-based trauma program, Cognitive-Behavioral Intervention for Trauma in Schools (CBITS), for adolescent substance abusers (ASAbusers); to assess the acceptability and feasibility of the integrated approach; and to pilot test the new program against standard care.

The investigators hypothesize that the intervention group, compared to the control group, will reduce substance use and symptoms for traumatic stress.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2012-07-18
• Study Start: 2013-04
• Study First Submitted QC: 2013-04-01
• Study First Posted: 2013-04-08
• Primary Completion: 2015-05
• Study Completion: 2015-05
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-27
• Last Update Posted: 2023-09-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 117

Inclusion Criteria

Youth

• Between ages of 13 & 19;
• meeting DSM IV criteria for substance abuse/dependence and PTSD;
• previously enrolled at recruitment site for at least 2 weeks;
• parent/guardian provides permission for minors to participate.

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Exclusion Criteria

Youth

• Not within the specified age range;
• presence of organic brain damage;
• inability to understand enrollment forms (e.g. Informed Assent/Consent Form)

Inclusion Criteria: Parents/Guardians

• Age 18 or above;
• parents/guardians of youth who meets inclusion criteria.

Exclusion Criteria: Parents/Guardians

• presence of organic brain damage.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Trauma-focused Substance Abuse Intervention	Trauma-focused Substance Abuse Intervention	See Intervention Arm description.

Primary Outcome Measures

Name	Time	Method
Urine Toxicology Screen (UTS)	Participants will be followed for an expected average of 12 weeks.	Urine samples will be collected twice per week at the treatment site to ensure validity of self-reports.
Child PTSD Symptom Scale (CPSS)	Change from Baseline in Child PTSD Symptom Scale at 8 weeks and change from Baseline in Child PTSD Symptom Scale at 12 weeks.	The CPSS will assess for severity of traumatic stress symptoms.
Timeline Follow-back (TFLB) Assessment of Substance Use	Participants will be followed for an expected average of 12 weeks.	The TLFB uses a blank calendar form and a series of questions to cue recall of alcohol and drug (AOD) use. The investigators will use the TLFB interview technique to assess AOD use weekly.

Secondary Outcome Measures

Name	Time	Method
Child Post-Trauma Attitudes Scale (C-PTAS)	Baseline & 8 weeks & 3 months	The C-PTAS will be used to assess trauma-related attitudes and beliefs.
Strengths & Difficulties Questionnaire (SDQ)	Baseline & 8 weeks & 3 months	The SDQ will be used to assess parent-report of behavioral problems.

Trial Locations

Locations (1)

Behavioral Health Services; 🇺🇸 Los Angeles, California, United States