NL-OMON26995
Not yet recruiting
Not Applicable
A feasibility study for the use of 18F-Canagliflozin to quantify individual differences in target-site exposure in diabetes patients
ConditionsType 2 diabetes mellitus
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Type 2 diabetes mellitus
- Sponsor
- niversity Medical Center Groningen
- Enrollment
- 9
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Type 2 diabetes
- •Age \= 40 years \<75 years
- •Written informed consent
Exclusion Criteria
- •Pregnant women and women of child\-bearing potential who are not using reliable contraception
- •eGFR \< 30 mL/min/1\.73 m2
- •Subjects on diuretics are allowed to participate but the dose should be stable for at least 4 weeks prior to screening
- •Subjects already on a SGLT2 inhibitor are allowed to participate, but the drug should be interrupted 1 week prior to the first study day till the end of the second study day
- •Subjects using a sulphonylurea.
- •Established peripheral arterial disease
- •Cardiovascular disease: myocardial infarction, angina pectoris, percutanous transluminal coronary angioplasty, coronary artery bypass grafting, stroke, heart failure (NYHA I\-IV) \< 3 months before inclusion
- •History of hypersensitivity to canagliflozin or another SGLT2 inhibitor
- •Active malignancy
- •Donation or loss of 400 ml or more of blood within 8 weeks prior to initial dosing
Outcomes
Primary Outcomes
Not specified
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