Disruption of Circadian Rhythm and Healthcare-related Infection in Patients With Severe Trauma
- Conditions
- Infection
- Interventions
- Other: blood samples
- Registration Number
- NCT02307747
- Lead Sponsor
- Assistance Publique Hopitaux De Marseille
- Brief Summary
Circadian rhythms, which play crucial roles in physiology, are emerging as important regulators of specific immune functions. Hospitalization in intensive care unit leads to a deep impairment of circadian rhythm. Infection is a frequent event during ICU hospitalization.
The investigators hypothesis is that in trauma patients the lack of circadian rhythm variations is associated with the occurrence of infection. The primary aim of the study is to assess the circadian variations of plasma Bmal1 in the occurrence of healthcare related infection during the 30 days after inclusion. The secondary aims are to assess the plasma expression of circadian genes (Clock, Cry1, Per3, and Rev-erba), the production of cytokines in plasma, and the concentration of cortisol, according to the occurrence of an infection.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- Trauma patients with an injury severity score > 15, requiring mechanical ventilation for at least 24 h during the first 48 h and an arterial catheter.
- Pregnant and lactating women
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description trauma patients blood samples Blood samples will be collected every 4 hours during 24 h, between day 2 and day 4 after inclusion
- Primary Outcome Measures
Name Time Method area under the curve representing the maximal expression of Bmal1 gene during the first 24 h following inclusion 24 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Assistance Publique Hôpitaux de Marseille
🇫🇷Marseille, France