Protocol Evaluation for Improved In Vitro Fertilization Outcomes
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Infertility
- Sponsor
- University of California, San Francisco
- Enrollment
- 2
- Locations
- 1
- Primary Endpoint
- Pregnancy Rate
- Status
- Terminated
- Last Updated
- 14 years ago
Overview
Brief Summary
Many infertile patients have a decreased chance of becoming pregnant when using in vitro fertilization (IVF). For these patients, many different treatments are available, but none of them have been shown to be better than the others. We are testing which of three different treatments are better than the others. Patients who are expected to have a decreased response to ovarian stimulation will be randomized to either a microflare protocol, an antagonist protocol, or a demi-halt protocol.
Detailed Description
Infertile patients with an anticipated poor response to ovarian stimulation will be randomized to one of three different protocols in their upcoming IVF cycle. Each of the protocols will be performed as is the standard of care with the addition of serum evaluation during the course of the stimulation as well as follicular fluid analysis which is obtained as a byproduct of the oocyte retrieval. Chart review will be performed to collect background characteristics (including age, ethnicity, previous fertility treatment), treatment response (such as oocyte number, embryo grade, embryo quality), and pregnancy outcome (such as miscarriage, singleton pregnancy, or higher-order multiple pregnancy). Statistical analysis will be performed to determine if one protocol leads to higher pregnancy rates and multivariate analysis will be performed to determine potential etiologic variables.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Infertile patients
- •Undergoing IVF
- •Antral Follicle Count Less than 10
- •Prior history of less than 5 oocytes generated during an IVF cycle
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Pregnancy Rate
Secondary Outcomes
- Cycle Cancellation Rates
- Number of Oocytes Generated
- Number of Embryos Generated
- Serum hormonal evaluation
- Follicular fluid evaluation