Novel Transcranial Treatments to Modulate Taste Reward and Body Perception Pathways in Eating Disorders
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- taste reward brain function activation confirmed by Functional magnetic resonance imaging (fMRI)
研究概览
简要总结
The primary aim of this study is to study how Repetitive Transcranial Magnetic Stimulation (rTMS) tailored to specific anorexia nervosa (AN) or bulimia nervosa (BN) brain activation alterations will promote recovery and to study how inhibitory tDCS (Transcranial Direct Current Stimulation) will reduce symptoms of body image distortion in a second sample of AN and BN groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Anorexia Nervosa subjects:
- •Meets DSM-5 criteria for anorexia nervosa (AN) either binge-eating/purging type or restricting-type:
- •Intense fear of gaining weight or becoming fat, even though underweight.
- •The ability to undergo an MRI, fMRI or other similar procedure requiring spending time in an enclosed space
- •Bulimia Nervosa subjects:
- •Meet DSM-5 criteria for bulimia nervosa (BN):
- •Self-induced vomiting; misuse of laxatives, diuretics, enemas, medication, fasting, excessive exercise.
排除标准
- •Electrolyte, blood count or kidney or liver function abnormalities.
- •No symptoms of alcohol or other substance abuse or dependence in the past 3 months,
- •No previous or current organic brain syndromes, dementia, psychotic disorders, somatization disorders, or conversion disorder, head trauma, indication of mental retardation or pervasive developmental disorder.
- •No antipsychotics, tricyclic antidepressants or Wellbutrin or other medication that may lower the seizure threshold.
- •Claustrophobia.
研究组 & 干预措施
TMS Treatment Group
15 sessions active Transcranial magnetic stimulation (TMS) treatment
干预措施: Transcranial magnetic stimulation (Procedure)
TMS Sham Group
15 sessions sham Transcranial magnetic stimulation (TMS) treatment
干预措施: Transcranial magnetic stimulation (Procedure)
tDCS Treatment Group
15 sessions active Transcranial direct current stimulation (tDCS) treatment
干预措施: Transcranial direct current stimulation (Procedure)
tDCS Sham Group
15 sessions sham Transcranial direct current stimulation (tDCS) treatment
干预措施: Transcranial direct current stimulation (Procedure)
结局指标
主要结局
taste reward brain function activation confirmed by Functional magnetic resonance imaging (fMRI)
时间窗: 3 years
Change in brain activation to taste reward paradigm
次要结局
- Change in self-reported measures related to eating disorder thoughts and behaviors(3 years)