Sensitivity and Specificity Study of Risk Factors for Intraductal Papillary Mucinous Neoplasms Degeneration at the Nancy CHRU (IPMN)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 57
- 试验地点
- 1
- 主要终点
- High-grade dysplasia or invasive cancer
研究概览
简要总结
Cystic lesions of the pancreas are frequent with a risk of degeneration into adenocarcinoma with pejorative prognosis.
IPMNs require characterization to clarify their potential for degeneration. Clinical and morphological risk factors for degeneration determine the monitoring rate and the indication for pancreatic surgery.
Pancreatic surgery remains invasive with high morbidity and mortality rates.
详细描述
This is a monoservice and monocentric retrospective study at the Nancy CHRU. We will study the risk factors for IPMNs degeneration in order to determine the most sensitive and specific.
To do this, we will use high-grade dysplasia or invasive cancer on the histological analysis of surgical specimens as the primary endpoint.
The study population will be patients with Branch Duct, Main Duct or mixed IPMNs operated at the Nancy CHRU between September 2009 and October 2021.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with a Branch Duct, Main Duct or mixed IPMNs operated at the Nancy CHRU between September 2009 and October 2021, adults and without legal protection measures
排除标准
- •IPMNs not operated
- •Pancreatic cancer without IPMNs
- •Patients whose state of health contraindicates pancreatic surgery
- •Non-adult patient
- •Patients under legal protection
结局指标
主要结局
High-grade dysplasia or invasive cancer
时间窗: 12 years
High-grade dysplasia or invasive cancer on histological analysis of the surgical specimen
次要结局
未报告次要终点
研究者
Jean-Baptiste CHEVAUX
PH
Central Hospital, Nancy, France