Exploration of Blood Biomarkers, Including Whole Blood Viscosity as a Prognostic Factor for Acute Pancreatitis
- Conditions
- Acute Pancreatitis
- Registration Number
- NCT04553783
- Lead Sponsor
- In Seok Lee
- Brief Summary
This study aims to evaluate the usefulness of blood viscosity as a prognostic factor in patients with acute pancreatitis. The study design is a single-arm prospective cohort observational study. Blood biomarkers including blood viscosity, C-reactive protein, hematocrit, and phosphate are measured and the correlation with the severity of acute pancreatitis will be analyzed.
- Detailed Description
Several scoring systems are used to evaluate the prognosis of acute pancreatitis, but they are rather complicated and clinically less useful. Blood viscosity is associated with hematocrit and inflammatory factors known to be related to the prognosis of acute pancreatitis, and our group's previous study which is not yet published showed that blood viscosity better predicts severe acute pancreatitis than other single factors such as C-reative protein. Therefore, this study aims to prospectively evaluate the usefulness of blood viscosity as a prognostic factor for acute pancreatitis. During the study period, the study is conducted on patients with acute pancreatitis between the ages of 19 and 70, and patients with acute pancreatitis after ERCP are excluded. Blood viscosities at initial and 24 hours after hospitalization, and serum phosphate, which have shown potential as a predictor of severity in post-ERCP pancreatitis in previous studies are measured. The association of these blood biomarkers with the severity of acute pancreatitis will be analyzed and compared with hematocrit, C-reactive protein, etc., which are known as a single prognostic predictor of acute pancreatitis.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 137
- Age 19-70 years old
- Acute pancreatitis
- Post-Endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prediction of severity of acute pancreatitis using initial blood viscosity 48hours after admission Evaluate initial blood viscosity as a predictor of the severity of acute pancreatitis
- Secondary Outcome Measures
Name Time Method Prediction of severity of acute pancreatitis using blood viscosity change after 24hours 24hours after admission Prediction of severity of acute pancreatitis using blood viscosity change after 24hours
Prediction of severity of acute pancreatitis using serum phosphate 48hours after admission Prediction of severity of acute pancreatitis using serum phosphate
Trial Locations
- Locations (1)
Seoul St. Mary's hospital
馃嚢馃嚪Seoul, Korea, Republic of