Exploration of Blood Biomarkers, Including Whole Blood Viscosity as a Prognostic Factor for Acute Pancreatitis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 137
- 试验地点
- 1
- 主要终点
- Prediction of severity of acute pancreatitis using initial blood viscosity
研究概览
简要总结
This study aims to evaluate the usefulness of blood viscosity as a prognostic factor in patients with acute pancreatitis. The study design is a single-arm prospective cohort observational study. Blood biomarkers including blood viscosity, C-reactive protein, hematocrit, and phosphate are measured and the correlation with the severity of acute pancreatitis will be analyzed.
详细描述
Several scoring systems are used to evaluate the prognosis of acute pancreatitis, but they are rather complicated and clinically less useful. Blood viscosity is associated with hematocrit and inflammatory factors known to be related to the prognosis of acute pancreatitis, and our group's previous study which is not yet published showed that blood viscosity better predicts severe acute pancreatitis than other single factors such as C-reative protein. Therefore, this study aims to prospectively evaluate the usefulness of blood viscosity as a prognostic factor for acute pancreatitis. During the study period, the study is conducted on patients with acute pancreatitis between the ages of 19 and 70, and patients with acute pancreatitis after ERCP are excluded. Blood viscosities at initial and 24 hours after hospitalization, and serum phosphate, which have shown potential as a predictor of severity in post-ERCP pancreatitis in previous studies are measured. The association of these blood biomarkers with the severity of acute pancreatitis will be analyzed and compared with hematocrit, C-reactive protein, etc., which are known as a single prognostic predictor of acute pancreatitis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 19-70 years old
- •Acute pancreatitis
排除标准
- •Post-Endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis
结局指标
主要结局
Prediction of severity of acute pancreatitis using initial blood viscosity
时间窗: 48hours after admission
Evaluate initial blood viscosity as a predictor of the severity of acute pancreatitis
次要结局
- Prediction of severity of acute pancreatitis using blood viscosity change after 24hours(24hours after admission)
- Prediction of severity of acute pancreatitis using serum phosphate(48hours after admission)
研究者
In Seok Lee
Professor
Seoul St. Mary's Hospital
