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临床试验/NCT04553783
NCT04553783Unknown不适用

Exploration of Blood Biomarkers, Including Whole Blood Viscosity as a Prognostic Factor for Acute Pancreatitis

In Seok Lee1 个研究点 分布在 1 个国家目标入组 137 人开始时间: 2020年3月10日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
137
试验地点
1
主要终点
Prediction of severity of acute pancreatitis using initial blood viscosity

研究概览

简要总结

This study aims to evaluate the usefulness of blood viscosity as a prognostic factor in patients with acute pancreatitis. The study design is a single-arm prospective cohort observational study. Blood biomarkers including blood viscosity, C-reactive protein, hematocrit, and phosphate are measured and the correlation with the severity of acute pancreatitis will be analyzed.

详细描述

Several scoring systems are used to evaluate the prognosis of acute pancreatitis, but they are rather complicated and clinically less useful. Blood viscosity is associated with hematocrit and inflammatory factors known to be related to the prognosis of acute pancreatitis, and our group's previous study which is not yet published showed that blood viscosity better predicts severe acute pancreatitis than other single factors such as C-reative protein. Therefore, this study aims to prospectively evaluate the usefulness of blood viscosity as a prognostic factor for acute pancreatitis. During the study period, the study is conducted on patients with acute pancreatitis between the ages of 19 and 70, and patients with acute pancreatitis after ERCP are excluded. Blood viscosities at initial and 24 hours after hospitalization, and serum phosphate, which have shown potential as a predictor of severity in post-ERCP pancreatitis in previous studies are measured. The association of these blood biomarkers with the severity of acute pancreatitis will be analyzed and compared with hematocrit, C-reactive protein, etc., which are known as a single prognostic predictor of acute pancreatitis.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
19 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age 19-70 years old
  • Acute pancreatitis

排除标准

  • Post-Endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis

结局指标

主要结局

Prediction of severity of acute pancreatitis using initial blood viscosity

时间窗: 48hours after admission

Evaluate initial blood viscosity as a predictor of the severity of acute pancreatitis

次要结局

  • Prediction of severity of acute pancreatitis using blood viscosity change after 24hours(24hours after admission)
  • Prediction of severity of acute pancreatitis using serum phosphate(48hours after admission)

研究者

发起方
In Seok Lee
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

In Seok Lee

Professor

Seoul St. Mary's Hospital

研究点 (1)

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