Resistance Exercise Training to Preserve Muscle Mass and Physical Function During Incretin-Based Weight Loss
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Change in Anterior Thigh Skeletal Muscle Volume
研究概览
简要总结
Treatment with appetite suppressant drugs, including incretin-based receptor agonists, generally leads to clinically meaningful weight loss and reduced cardiometabolic risk. However, weight loss may include not only loss of adipose tissue but also loss of skeletal muscle mass, which ultimately may impair physical function and metabolic health.
Resistance training is an effective strategy to maintain or increase skeletal muscle mass during weight loss, but its effects during treatment with appetite suppressant obesity medications have been studied insufficiently. This study will investigate whether unilateral resistance training during incretin-based receptor agonist treatment can preserve or improve skeletal muscle mass. Additionally, the study will determine whether preservation of muscle is accompanied by the preservation of muscle function and/or molecular adaptations in skeletal muscle, adipose tissue and blood.
Participants will be adults with obesity who are about to start treatment with an incretin-based receptor agonist as part of routine clinical care. During the 13-week intervention, participants will perform supervised unilateral resistance training two times per week, training one leg while the other leg serves as an internal control. Data and tissue collection will take place before treatment start and after 13 weeks. Assessments include whole-body magnetic resonance imaging, blood sampling, skeletal muscle and adipose tissue biopsies, physical function tests, questionnaires, and monitoring of physical activity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18-64 years with obesity.
- •Planned initiation of incretin-based obesity pharmacotherapy as part of routine clinical care.
- •Able to participate in supervised unilateral resistance training.
- •Able to complete physical function tests.
- •Able to attend study visits at the study center.
- •Able to provide written informed consent in the Swedish language.
排除标准
- •Contraindication to magnetic resonance imaging.
- •Medical condition preventing resistance training or physical function testing.
- •Medical condition preventing skeletal muscle or adipose tissue biopsy.
- •Inability to understand study information in Swedish or provide informed consent.
研究组 & 干预措施
Incretin treatment combined with unilateral resistance training
Participants will initiate incretin-based receptor agonist treatment as part of routine clinical care. The study intervention consists of supervised unilateral resistance training performed twice weekly for 13 weeks. No incretin-based medication is assigned or administered by the study.
干预措施: Unilateral Resistance Training (Behavioral)
结局指标
主要结局
Change in Anterior Thigh Skeletal Muscle Volume
时间窗: From baseline to 13 weeks
Change in skeletal muscle volume (L) of the anterior thigh muscles, measured by magnetic resonance imaging from baseline to 13 weeks. The primary comparison will be the difference in change from baseline to 13 weeks between the trained leg and the untrained contralateral leg.
次要结局
- Change in knee extension strength(From baseline to 13 weeks)
- Change in muscle fatigue tolerance(From baseline to 13 weeks)
- Change in whole-body skeletal muscle mass(From baseline to 13 weeks)
- Change in total body fat volume(From baseline to 13 weeks)
- Change in liver fat fraction(From baseline to 13 weeks)
- Change in abdominal subcutaneous adipose tissue volume(From baseline to 13 weeks)
- Change in visceral adipose tissue volume(From baseline to 13 weeks)
- Change in skeletal muscle fat fraction(From baseline to 13 weeks)
研究者
Eric Emanuelsson
Postdoctoral Researcher
Karolinska Institutet