L-NMMA Dose-response Study in Healthy Subjects
- Registration Number
- NCT01070940
- Lead Sponsor
- Regional Hospital Holstebro
- Brief Summary
The purpose of this study is to investigate the effect of different levels of nitric oxide inhibition on blood pressure and arterial stiffness in healthy subjects. L-NMMA, an inhibitor of the nitric oxide synthase, is administered as bolus injection followed by continuous infusion, and is expected to raise blood pressure and arterial stiffness according to L-NMMA dose.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 12
Inclusion Criteria
- Healthy males
- Age 18-35 years
- BMI 18.5-30.0
Exclusion Criteria
- Tobacco or illicit drug use
- Current use of any prescription or non-prescription drugs
- Alcohol abuse
- History of heart failure, lever failure, chronic kidney disease or cerebral insult
- Diabetes
- Clinical or paraclinical signs of infection
- Pathologic ECG
- Ambulatory blood pressure >140/90 mmHg
- Abnormal blood or urin screening tests
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Intravenous L-NMMA dose 1 NG-monomethyl-L-arginine (L-NMMA) - Isotonic saline infusion Placebo - Intravenous L-NMMA dose 2 NG-monomethyl-L-arginine (L-NMMA) - Intravenous L-NMMA dose 3 NG-monomethyl-L-arginine (L-NMMA) -
- Primary Outcome Measures
Name Time Method Systolic blood pressure 6 hours
- Secondary Outcome Measures
Name Time Method GFR 6 hours Arterial Stiffness 6 hours Fractional excretion of sodium 6 hours Fractional excretion of potassium 6 hours Plasma renin concentration 6 hour Plasma angiotensin II 6 hours Plasma aldosterone 6 hour
Trial Locations
- Locations (1)
Departments of Medical Research
🇩🇰Holstebro, Denmark