Effect of Precise Grip Strength Training on PICC Catheter-Related Thrombosis in Cancer Patients

Not Applicable

Completed

• Conditions: Lung Cancer; Stomach Cancer; Liver Cancer; Colon Cancer; Breast Cancer; Rectal Cancer
• Interventions: Behavioral: Health education on routine grip strength training; Behavioral: Use maximum strength grip training; Behavioral: Precision grip training

• Registration Number: NCT05638048
• Lead Sponsor: Junyan Zhao

Brief Summary

In this study, color Doppler ultrasound diagnostic instrument and electronic grip device were used to determine the best grip strength of patients with tumor PICC catheterization, formulate precise and standardized grip strength training guidance for them, provide personalized functional exercise health education, and observe the impact of precise grip strength training guidance on Peripheral central venous catheter-associated thrombosis. To provide a reference for clinical prevention of Peripheral central venous catheter-associated thrombosis in the future.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-07-10
• Study First Submitted: 2022-08-24
• Study First Submitted QC: 2022-12-01
• Study First Posted: 2022-12-06
• Primary Completion: 2022-12-31
• Study Completion: 2023-01-10
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-02
• Last Update Posted: 2023-02-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 270

Inclusion Criteria

• Cancer patients undergoing chemotherapy throughout their treatment in our hospital
• Patients with PICC implanted for the first time and maintained at our hospital;
• Age 18-60 years;
• Normal cognitive function;
• the clenching movement is barrier-free;
• The material and performance of PICC catheter are silicone three-way valve catheter;
• Catheter placement under the guidance of portable color Doppler ultrasound diagnostic instrument;
• Voluntarily participate and sign the informed consent form.

Exclusion Criteria

• Patients treated with combined radiotherapy;
• Patients with coagulation dysfunction;
• Patients who need to use anticoagulant drugs due to underlying diseases;
• Puncture times more than 1 time;
• The blood flow velocity of catheterization vessel in calm state was less than 4.78cm/s.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
The control group	Health education on routine grip strength training	Patients were routinely implanted with PICC and received routine health education. The content of health education included face-to-face language explanation of the whole process of catheter knowledge, issuing catheter maintenance manual, issuing ordinary grip ball and telling how to use it, and follow-up.
Experiment 1 set	Use maximum strength grip training	Patients were routinely implanted with PICC, and the optimal duration-relaxation time of grip strength training was adopted on the basis of health education in the control group.
Experiment 2 set	Precision grip training	On the basis of control group 1. Determine the best grip strength On the basis of the control group, color Doppler ultrasound and electronic grip force were used to record the optimal grip strength of patients to achieve effective blood flow velocity before and 24 hours after PICC insertion. 2. Design precise grip strength training guidance program On the basis of the control group, the patients were instructed to perform grip strength training according to the determined best grip strength and the best duration of clenching and relaxation time.

Primary Outcome Measures

Name	Time	Method
Incidence of Peripheral central venous catheter-associated thrombosis in patients with PICC tube	8 weeks	Before catheterization, 24 hours after catheterization, and weekly maintenance, color Doppler ultrasound diagnostic instrument was used to diagnose venous thrombosis (including asymptomatic thrombosis) and its classification. The patients were observed for 8 weeks.

Secondary Outcome Measures

Name	Time	Method
Patients' satisfaction with health education after PICC catheterization	8 weeks	At the end of the intervention, the patients' attitude towards PICC catheterization health education questionnaire (self-made) was distributed to the study subjects, and the satisfaction of the study subjects with the health education after PICC catheterization was learned through the questionnaire.
Analysis of the influencing factors of Peripheral central venous catheter-associated thrombosis formation	8 weeks	By investigating the baseline data of patients, the related factors affecting the formation of PICC-CRT in patients with tumor tube in the baseline data of the same group were analyzed and compared.
Hemodynamic changes of the patient	8 weeks	During weekly maintenance, color Doppler ultrasound was used to measure the blood velocity of the arm axillary vein on the side of the catheter, and the maximum blood velocity (Vmax, cm/s) was recorded.

Trial Locations

Locations (1)

Qianfoshan Hospital; 🇨🇳 Jinan, Shandong, China