Child Development and Genetic Biomarkers
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Child Development
- Sponsor
- Chang Gung Memorial Hospital
- Enrollment
- 446
- Locations
- 1
- Primary Endpoint
- Scores of cognitive function 1
- Last Updated
- 5 years ago
Overview
Brief Summary
A study of the relation between genetic biomarkers and child development in Taiwan.
Detailed Description
The interaction between gene and environment (G×E) can be a very complicated process that influences child development. As a pilot study of child development biomarkers, this study investigates genes related to child development.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Scores of cognitive function 1
Time Frame: baseline
Bayley Scales of Infant and Toddler Development (Scores from 0 to 140, higher scores mean a better outcome.)
Scores of cognitive function (2 y/o to 6 y/o)
Time Frame: baseline
Wechsler Preschool and Primary Scale of Intelligence (Scores from 0 to 200, higher scores mean a better outcome.)
Scores of cognitive psychological function
Time Frame: baseline
Cantab MOT, PAL, SWM, SOC tests
Scores of motor ability 2
Time Frame: baseline
Measure of Grip and Grasp (Higher scores mean a better outcome.)
Gene test (WES3)
Time Frame: baseline
Whole-Exome Sequencing (Use Picard to screen out the variant discovery and genotyping.)
Gene test (WES4)
Time Frame: baseline
Whole-Exome Sequencing (Use Genome Analysis Toolkit (GATK) to screen out the variant discovery and genotyping.)
Scores of cognitive function (6 y/o to 16 y/o)
Time Frame: baseline
Wechsler Intelligence Scale for Children (Scores from 0 to 200, higher scores mean a better outcome.)
Scores of social behavior 2
Time Frame: baseline
Swanson, Nolan, and Pelham, Version IV (Lower scores mean a better outcome.)
Scores of motor ability 1
Time Frame: baseline
The Berry-Buktenica Developmental Test of Visual-Motor Integration (Scores from 0 to 81, Higher scores mean a better outcome.)
Gene test (WES2)
Time Frame: baseline
Whole-Exome Sequencing (Use Samtools86 to screen out the variant discovery and genotyping.)
Scores of cognitive function 3
Time Frame: baseline
Test of Nonverbal Intelligence-Fourth Edition (Scores from 0 to 60, higher scores mean a better outcome.)
Gene test (WES1)
Time Frame: baseline
Whole-Exome Sequencing (Use Burrows-Wheeler Aligner (BWA) 85 to screen out the variant discovery and genotyping.)
Scores of language function 2
Time Frame: baseline
Preschool Language Impaired Scale(PLS)/Language Impaired Scale(LS) (PLS: Scores from 0 to 65, higher scores mean a better outcome. LS: Scores from 0 to 73, higher scores mean a better outcome.)
Scores of social behavior 1
Time Frame: baseline
Clancy Behavior Scale (Scores from 0 to 42, lower scores mean a better outcome.)
Scores of language function
Time Frame: baseline
Peabody Picture Vocabulary Test-Revised (Scores from 0 to 124, higher scores mean a better outcome.)
Scores of general development
Time Frame: baseline
Comprehensive Developmental Inventory for Infants and Toddlers (Higher scores mean a better outcome.)
Gene test (Mircoarray)
Time Frame: baseline
Microarray (Use Axiom Genome-Wide TWB 2.0 Array Plate (TWB 2.0) to analyze SNPs of disease-related biomarkers.)
Secondary Outcomes
- Scores of quality of life(baseline)
- Scores of participation(2-5 y/o)(baseline)
- Scores of participation(>6 y/o)(baseline)
- Scores of activities(baseline)