Compare Bleeding Risk Between Cold and Hot Snaring Polypectomy for Small Colorectal Polyp: a Randomized Control Trial

Not Applicable

Completed

• Conditions: Colorectal Polyp
• Interventions: Device: Polypectomy

• Registration Number: NCT03373136
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

In this randomized control trial the investigators aim to compare the bleeding complication between cold snaring and hot snaring polypectomy with a large sample size.

Detailed Description

The investigators will enroll subjects who receive screening or surveillance colonoscopy with small colorectal polyp, 4 to10 mm in size, from multiple centers in Taiwan. Subjects who are less than 40 years old and has contraindication will be excluded from this study. All the candidates for enrollment will sign the inform consent at the outpatient clinic. Once the candidate has the target lesion, polyp sized 4 to 10 mm, at colonoscopy will be randomized into either cold snaring or hot snaring polypectomy group. In the group with cold snaring, polypectomy will be done without electrocautery. In the hot snaring group, the polypectomy will be performed with electrocautery. The bowel preparation and colonoscopy insertion are the same in both groups as conventional colonoscopy method. The colonoscopy will be performed by experienced endoscopies who performed more than 100 polypectomies per year.

Study Timeline

• Study First Submitted: 2017-11-29
• Study First Submitted QC: 2017-12-12
• Study First Posted: 2017-12-14
• Study Start: 2018-02-07
• Status Verified: 2020-08
• Primary Completion: 2020-08-14
• Study Completion: 2020-08-30
• Last Update Submitted: 2020-10-12
• Last Update Posted: 2020-10-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 4270

Inclusion Criteria

• Candidate has the target lesion, polyp sized 4 to 10 mm, at colonoscopy

Exclusion Criteria

• Subjects who are less than 40 years old and has contraindication will be excluded from this study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cold snaring	Polypectomy	Polypectomy will be done without electrocautery
Hot snaring	Polypectomy	Polypectomy will be performed with electrocautery

Primary Outcome Measures

Name	Time	Method
Delayed bleeding rate	2 weeks	Anal bleeding with spontaneously stop; drop of Hb more than 2 gm/dl in comparison with baseline; transfusion needed; hemostasis by : colonoscopy, angiography, surgery

Trial Locations

Locations (1)

Department of Internal Medicine, College of Medicine, National Taiwan University; 🇨🇳 Taipei, Taiwan