Comparison of blood lactate-to-bicarbonate ratio versus blood lactate alone for predicting outcomes in children with septic shock
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- To compare in-hospital mortality (defined as death during the hospital admission for septic shock) of children with septic shock using blood lactate-to-bicarbonate ratio versus blood lactate alone as predictors.
研究概览
简要总结
This observational study at GTB Hospital (Aug 2025–Nov 2026) evaluates whether the blood lactate-to-bicarbonate ratio is a better predictor of clinical outcomes than blood lactate alone in children aged 1–12 years with septic shock. It compares in-hospital mortality, length of stay, ventilatory support needs, and organ dysfunction (p-SOFA scores) across 130 patients. Arterial blood gas analysis will be used to assess biomarkers and guide outcome predictions.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 1.00 Year(s) 至 12.00 Year(s)（—）
- 性别
- All
入选标准
- •Children diagnosed with septic shock of age 1 to 12 years.
排除标准
- •Children with known metabolic disorders or inborn errors of metabolism.
- •Children with chronic liver or kidney disease.
- •Children on immunosuppressive therapy or known malignancy.
结局指标
主要结局
To compare in-hospital mortality (defined as death during the hospital admission for septic shock) of children with septic shock using blood lactate-to-bicarbonate ratio versus blood lactate alone as predictors.
时间窗: At baseline
次要结局
- To correlate length of hospital stay (in days) ,requirement for mechanical ventilation and duration of mechanical ventilation to blood lactate-to-bicarbonate ratio and blood lactate alone.(At time of discharge or death)
- To correlate p-SOFA score at baseline to blood lactate-to-bicarbonate ratio and blood lactate alone.(Within 6 hours of admission)
研究者
Dr Jyoti Antil
University college of medical sciences, GTB hospital