Prediction of Coronary Artery Disease Severity by Epicardial Adipose Tissue Thickness

• Conditions: Myocardial Infarction
• Interventions: Radiation: echocardiography and cardiac magnetic resonance

• Registration Number: NCT03308539
• Lead Sponsor: Osama Fekry

Brief Summary

is to test the hypotheses that epicardial adipose tissue can be a marker of severity of coronary artery disease in myocardial infarction patients

Detailed Description

epicardial adipose tissue is defined as the adipose tissue between the visceral pericardium and the outer margin of the myocardium which can be considered an endocrine organ that secretes pro-inflammatory and anti-inflammatory cytokines and chemokines including adiponectin.as investigators know, inflammatory response is an important factor in the coronary atherogenesis. Therefore,epicardial adipose tissue is likely to be connected with the severity of coronary artery disease.Recent studies showed that the thickness of the epicardial adipose tissue in patients with coronary artery disease was greater than that with normal coronary arteries.

epicardial adipose tissue will be assessed using transthoracic echocardiography and cardiac magnetic resonance which allows for an accurate volumetric quantification of epicardial fat.

Study Timeline

• Status Verified: 2017-10
• Study First Submitted: 2017-10-06
• Study First Submitted QC: 2017-10-11
• Last Update Submitted: 2017-10-11
• Study First Posted: 2017-10-12
• Last Update Posted: 2017-10-12
• Study Start: 2017-11-01
• Primary Completion: 2017-12-01
• Study Completion: 2018-09-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Not provided

Exclusion Criteria

1. contraindication for cardiac magnetic resonance.
2. Patients who previously underwent coronary artery bypass grafting or percutaneous coronary angiography prior to admission
3. history of chronic kidney disease with glomerular filtration rate <30 mL/min
4. pericardial and/or pleural effusion.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
myocardial infarction patients	echocardiography and cardiac magnetic resonance	transthoracic echocardiography and cardiac magnetic resonance

Primary Outcome Measures

Name	Time	Method
measurement of epicardial adipose tissue as marker of severity of coronary artery disease in myocardial infarction patients.	one year	epicardial adipose tissue measurement using transthoracic echocardiography and cardiac magnetic resonance

Trial Locations

Locations (1)

Jacqueline George; 🇪🇬 Assiut, Single, Egypt