Efficacy of short course high-dose amoxicillin in the treatment of non-severe community acquired-pneumonia in children: A double-blind, randomised controlled trial

Medical Research Council Laboratories (Gambia)0 个研究点目标入组 905 人开始时间: 2010年6月3日最近更新: 2015年1月13日

试验速览

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•1. Aged 2 to 59 months
•2. Either sex
•3. Nutritional status: Weight-for-height > 70% of National Center for Health Statistics (NCHS) reference without oedema
•4. Non-severe pneumonia according to WHO definition: if the child has fast breathing with cough or difficult breathing and there is no chest indrawing or other danger signs

•1. Having severe pneumonia or very sever disease or if needs oxygen
•2. Needed antibiotic, steroid, theophylline or digitalis for treatment of any other condition
•3. Had been enrolled in the trial for an earlier episode of pneumonia
•4. Was admitted in a hospital in the previous month
•5. History of hypersensitivity or intolerance to amoxicillin or co-trimoxazole
•6. History of receiving any antibiotic within last 48 hours, this was be confirmed from health cards or village health workers
•7. A history of three or more episodes of wheeze, acute bronchial asthma
•8. Evidence of underlying haematologic, renal, hepatic or cardiovascular disease
•9. Chronic steroid use or concomitant treatment with theophylline or digitalis glycosides
•10. Living outside the study area

发起方

Medical Research Council Laboratories (Gambia)