High-Intensity Interval Training Improves Aerobic Capacity and Abolishes the Decline in Blood Glucose Observed During Moderate-Intensity Continuous Training Sessions in People With Type 1 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Maximal aerobic capacity
研究概览
简要总结
Few people with type 1 diabetes achieve exercise guidelines and many programmes designed to increase physical activity have failed. High-intensity interval training (HIT) has been shown to be a time-efficient alternative to traditional moderate-intensity continuous training (MICT) in various groups without type 1 diabetes. A single bout of HIT does not increase the risk of hypoglycaemia in people with type 1 diabetes. This study aimed to assess whether HIT a safe, effective and time-efficient training strategy to improve cardio-metabolic health and reduce the risk of hypoglycaemia in people with type 1 diabetes.
详细描述
This study aimed to investigate whether 1) six weeks of high-intensity interval training (HIT) induces similar improvements in cardio-metabolic health markers as moderate-intensity continuous training (MICT) in people with type 1 diabetes, and 2) whether HIT abolishes acute reductions in plasma glucose observed following MICT sessions. Fourteen sedentary individuals with type 1 diabetes (n=7 per group) completed six weeks of HIT or MICT 3 times per week. Pre- and post-training measurements were made of 24h interstitial glucose profiles (using continuous glucose monitors (CGMS)) and cardio-metabolic health markers (V ̇O2peak, blood lipid profile and aortic pulse wave velocity; aPWV). Capillary blood glucose concentrations were assessed before and after exercise sessions throughout the training programme to investigate changes in blood glucose during exercise in the fed state.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 接受健康志愿者
- 否
入选标准
- •duration of type 1 diabetes >6 months
- •basal bolus regimen
- •no significant history of hyper- or hypoglycaemia (determined from medical history)
排除标准
- •duration of type 1 diabetes <6 months,
- •insulin pump therapy
- •significant history of hyper- or hypoglycaemia (determined from medical history)
- •obesity (BMI >30 kg∙m-2)
- •pregnancy or planning pregnancy
- •uncontrolled hypertension (>180/100 mmHg)
- •angina, autonomic neuropathy
- •taking any medication that affects heart rate
- •major surgery planned within 6 weeks of the study
- •severe nonproliferative
- •unstable proliferative retinopathy
研究组 & 干预措施
HIT training
6 weeks of high-intensity interval training (HIT)
干预措施: HIT (Other)
Moderate intensity training
6 weeks of moderate-intensity continuous training (MICT)
干预措施: MICT (Other)
结局指标
主要结局
Maximal aerobic capacity
时间窗: change in baseline maximal aerobic capacity at 6 weeks
Maximal aerobic capacity test pre and post 6-week training intervention
次要结局
- Vascular stiffness(change in baseline vascular stiffness at 6 weeks)
研究者
Sam Shepherd
Dr Sam Shepherd, Principle Investigator
Liverpool John Moores University