Bioimpedance of Human Tissue of the Upper Arm and Arterial Distension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Conductivities and permittivities in the spectral region from 1 KHz to 1 MHz.
研究概览
简要总结
The overall objectives were to investigate if characteristic dimensions for tissue and vessels determined from measured bioimpedance spectra would provide the same values as dimensions determined from MR images of the upper arm and verify that temporal variations of impedances could be converted to blood pressure.
详细描述
It is emphasized that measurements of pulse wave velocity was not a part of this trial, which implies that only uncalibrated blood pressures could be measured. The specific objectives were:
- To determine conductivities and permittivities in the spectral region from 1 KHz to 1 MHz for persons with: (a) a normal distribution of fat and muscles, (b) exceptionally thick layers of subcutaneous fat, and (c) exceptionally thin layers of subcutaneous fat. Both sexes should be represented.
- To verify that temporal variations synchronous with the heartbeat could be measured on all three groups.
Hypotheses:
A. That experimentally in vivo determined electrical parameters for tissues would differ considerably from theoretical values and from values measured in vitro experiments.
B. That the variations of the electrical parameters would exhibit little variation from person to person.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 - 80 years
- •Mental ability to understand information to test subjects
排除标准
- •Serious illness
- •Allergic reactions to ECG or EMG electrodes
- •Mentally unstable or unable to perceive instructions
- •Metal implants
- •Claustrophobia
- •Disqualified for MR scanning
结局指标
主要结局
Conductivities and permittivities in the spectral region from 1 KHz to 1 MHz.
时间窗: 1 hour
Measured on persons with: (a) a normal distribution of fat and muscles, (b) exceptionally thick layers of subcutaneous fat, and (c) exceptionally thin layers of subcutaneous fat. Both sexes should be represented. Muscles and vessels followed expectations based on litterature values for electrical properties. Subcutaneous fat had a higher conductivity and permittivity than predicted from literature values in all cases.
次要结局
- Temporal variations synchronous with the heartbeat(1 hour)