A clinical trial to study and compare the effect of aloe vera and turmeric in patients with oral lichen planus.

Phase 2

Completed

• Conditions: Other disorders of skin and subcutaneous tissue in diseases classified elsewhere,

• Registration Number: CTRI/2019/08/020856
• Lead Sponsor: Sarkate Priyadarshani Rustum

Brief Summary

Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease. It affects 0.2–1.9% of the population. Clinically, the disease is characterized by different types of lesions – papular, reticular and in the form of plaques – that can alternate with erosive and ℠or ulcerative areas.

The disease can produce considerable morbidity and alter patient quality of life, particularly in the presence of ulcerative lesions. Extensive research and numerous trials have been conducted to determine the most effictive and safe treatments for OLP, but currently there exists no definite treatment protocol for the management of OLP.

In general, topical formulations are generally preferred as it has fewer adverse effects. From all the treatment modalities aloe vera and Curcumene (turmeric) shows good herbal modalities for OLP with no or minimal side effects so these study prompted us to evaluate and correlate the clinical efficacy of turmeric and aloe vera in the patients of OLP.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-08-25
• Study Completion: 2020-09-18
• Last Update Posted: 2020-09-25

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Clinically confirmed Oral lichen Planus and willing to take part in the study.
• Patients willing to participate after he / she is made aware of all possible treatment modalities for lichen planus.
• Patients who have received no treatment for OLP in the last 2 weeks in the case of topical treatments, or in the last 4 weeks in the case of systemic therapies.

Exclusion Criteria

• Evidence of lichenoid reaction in clinical assessment.
• Patients with other white lesions of oral cavity.
• Patients with other mucocutaneous lesions of oral cavity.
• Pregnancy, lactation 5.
• History of allergic reactions to Aloe Vera or Turmeric.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome is measured by VAS scale and modified oral mucositis index.	Initial,1,2,and 3 month

Secondary Outcome Measures

Name	Time	Method
The primary outcome is measured by VAS scale and modified oral mucositis index.	Initial,1,2,and 3 month

Trial Locations

Locations (1)

MGM Dental College; 🇮🇳 Thane, MAHARASHTRA, India

MGM Dental College

🇮🇳Thane, MAHARASHTRA, India

Sarkate Priyadarshani Rustum

Principal investigator

7588847108

priyasarkate2605@gmail.com