Comparative Evaluation of Clinical Efficacy of Aloe Vera and Turmeric in Clinically Diagnosed Oral Lichen Planus Cases-A Randomized Clinical Trial.
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The primary outcome is measured by VAS scale and modified oral mucositis index.
研究概览
简要总结
Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease. It affects 0.2–1.9% of the population. Clinically, the disease is characterized by different types of lesions – papular, reticular and in the form of plaques – that can alternate with erosive and ℠or ulcerative areas.
The disease can produce considerable morbidity and alter patient quality of life, particularly in the presence of ulcerative lesions. Extensive research and numerous trials have been conducted to determine the most effictive and safe treatments for OLP, but currently there exists no definite treatment protocol for the management of OLP.
In general, topical formulations are generally preferred as it has fewer adverse effects. From all the treatment modalities aloe vera and Curcumene (turmeric) shows good herbal modalities for OLP with no or minimal side effects so these study prompted us to evaluate and correlate the clinical efficacy of turmeric and aloe vera in the patients of OLP.
研究设计
- 研究类型
- Interventional
- 分配方式
- Random Number Table
- 盲法
- Open Label
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •Clinically confirmed Oral lichen Planus and willing to take part in the study.
- •Patients willing to participate after he / she is made aware of all possible treatment modalities for lichen planus.
- •Patients who have received no treatment for OLP in the last 2 weeks in the case of topical treatments, or in the last 4 weeks in the case of systemic therapies.
排除标准
- •Evidence of lichenoid reaction in clinical assessment.
- •Patients with other white lesions of oral cavity.
- •Patients with other mucocutaneous lesions of oral cavity.
- •Pregnancy, lactation
- •History of allergic reactions to Aloe Vera or Turmeric.
结局指标
主要结局
The primary outcome is measured by VAS scale and modified oral mucositis index.
时间窗: Initial,1,2,and 3 month
次要结局
- The primary outcome is measured by VAS scale and modified oral mucositis index.(Initial,1,2,and 3 month)