Effect of amlodipine before embryo transfer on pregnancy rate in ICSI cycles

Phase 3

Recruiting

• Conditions: Repeated implantation failure.; Female infertility of uterine origin; N97.2

• Registration Number: IRCT20101227005485N11
• Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

Women aged 18 to 40 with ICSI <38 and ICSI candidate for frozen embryo transfer
Typically, higher baseline blood pressure Equal to 60/100 mm Hg before embryo transfer.
The serum FSH level is not higher than 14 mli/iu
Patients who have a normal uterine cavity in hysterosalpingography
Those who do not contraindicate the use of Amlodipine, such as heart and liver patients
Patients who do not have a history of irregular heart rate or who do not consume blood pressure pills.

Exclusion Criteria

Patients who have been taking medication interfered with Amlodipine over a month
The women who have a blood pressure of 60/100 (mmHg) or less just before the prescribing the medicine.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean Pulsatility index of uterine artery. Timepoint: Before intervention and 2 weeks later. Method of measurement: Doppler sonography of uterine arteries.;Mean resistance index of uterine artery. Timepoint: Before intervention and 2 weeks later. Method of measurement: Doppler sonography of uterine arteries.

Secondary Outcome Measures

Name	Time	Method
Pregnancy rate. Timepoint: 12 days following embryo transfer. Method of measurement: Blood test, BHCG.;Implantation rate: Gestational sac. Timepoint: in 6 weeks after pregnancy. Method of measurement: vaginal sonography.