NCT05873647招募中不适用
Effect of Inhaled Nitric Oxide on Pulmonary Ventilation/Perfusion Ratio Assessed by Electrical Impedance Tomography in Patients With Acute Respiratory Distress Syndrome
Wuhan Union Hospital, China1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2023年5月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Lung ventilation/perfusion ration
研究概览
简要总结
Electrical impedance tomography was used to monitor changes in pulmonary perfusion distribution and V/Q ratio before and after iNO in patients with acute respiratory distress syndrome to investigate the factors predicting iNO reactivity and the physiological mechanism underlying changes in oxygenation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged ≥ 18 years;
- •Patients are intubated and mechanically ventilated.
排除标准
- •EIT contraindications such as chest wound dressing, pacemaker installation, defibrillator, etc;
- •With a history of cerebral hemorrhage in the past half year, as well as bleeding in any site of the body;
- •Pneumothorax;
- •Medium or massive pleural effusion;
- •Refractory shock;
- •With chronic kidney disease
- •Atrial fibrillation or other malignant arrhythmia leads to a decrease in cardiac output;
- •Failure to sign informed consent
结局指标
主要结局
Lung ventilation/perfusion ration
时间窗: 3 hours
Lung ventilation/perfusion ration after iNO assessed by EIT
次要结局
- Lung perfusion distribution(30minutes and 3 hours)
- Shunting(30minutes and 3 hours)
- Dead space(30minutes and 3 hours)
- Right ventricular function(30minutes and 3 hours)
- Oxygenation index(30minutes and 3 hours)
- Static respiratory compliance (Crs)(30minutes and 3 hours)
- Arterial partial pressure of carbon dioxide (PaCO2)(30minutes and 3 hours)
- Cardiac output(30minutes and 3 hours)
研究者
XiaoJing Zou,MD
Clinical Professor
Wuhan Union Hospital, China
研究点 (1)
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