Evaluation the Efficacy of a Herbal Licorice on Reducing Salivary Streptococcus Mutans Levels (A Randomized Clinical Trial)
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Cairo University
- Enrollment
- 52
- Primary Endpoint
- salivary bacterial count
Study Overview
Brief Summary
To compare the effect of a natural herbal licorice containing preventive measure alternative to chlorohexidine preventive measure to decrease the effect of streptococcus mutans.
Detailed Description
A total number of fifty-two patients will be enrolled in the study. They will be divided into two groups: study group and control group. Study group will be subjected to licorice mouthwash and the control will be subjected to chlorohexidine mouth wash. Salivary bacterial count will be evaluated for both groups.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •over 18 years old
- •co-operative patients
- •not allergic to licorice
- •not allergic to chlorohexidine
Exclusion Criteria
- •pregnancy
- •allergic patients to licorice
- •allergic patients to chlorohexidine
- •lack of compliance
- •evidence of parafunctional habits
- •patients with periodontal disease
- •xerostomia
- •participants that receive any microbial agent two weeks prior to the study
Arms & Interventions
licorice extract mouthwash
administration of a mouthwash containing licorice as a preventive measure to high caries risk patients (faculty of pharmacy, cairo university)
Intervention: licorice extract mouthwash (Other)
chlorohexidine mouthwash
administration of chlorohexidine 0.2% in 1:1 diluation mouthwash that is broad spectrum antimicrobial activity to high caries risk patients
Intervention: chlorohexidine mouthwash (Other)
Outcomes
Primary Outcomes
salivary bacterial count
Time Frame: after one week
streotococcus mutans bacterial count
Secondary Outcomes
No secondary outcomes reported
Investigators
Nancy Helmy Blamon Mikhael
Assistant lecturer
Cairo University