Observing the Relationship of Fibroblast Growth Factor and Fibroblast in Thyroid Eye Disease

• Conditions: Graves Ophthalmopathy

• Registration Number: NCT03324022
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Graves' orbitopathy (GO) affects about 50% of patients with Graves' disease (GD), and some cannot be cured by current treatments. Orbital fibroblasts involves in the pathogenesis of GO by producing glycosaminoglycans and inflammatory cytokines. Since fibroblast growth factors (FGFs) binding to FGF receptors (FGFRs) can induce proliferation and differentiation of fibroblasts, investigators would like to measure the expression of FGFs and FGFRs in GO patients to see if inhibition of FGF-FGFR pathway has potential in treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-12-25
• Status Verified: 2017-10
• Study First Submitted: 2017-10-16
• Study First Submitted QC: 2017-10-24
• Study First Posted: 2017-10-27
• Last Update Submitted: 2017-10-29
• Last Update Posted: 2017-10-31
• Primary Completion: 2017-12-25
• Study Completion: 2020-12-25

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• diagnosed as thyroid eye disease
• suggested to accept orbital decompression

Exclusion Criteria

• age below 20 or above 80
• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum concentration of selected growth factors	1 year	Investigators would like to measure fibroblast growth factors concentration (ug/mL) by ELISA according to the manufacturers' instruction

Secondary Outcome Measures

Name	Time	Method
RNA expression level of selected growth factor receptors	1 year	Investigators would like to measure adipogenesis-related genes expression level comparing to house-keeping gene using real-time PCR

Trial Locations

Locations (1)

National Taiwan University Hospital Taipei, Taiwan; 🇨🇳 Taipei, Taiwan