NCT03324022Unknown不适用
Observing the Relationship of Fibroblast Growth Factor and Fibroblast in Thyroid Eye Disease
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Serum concentration of selected growth factors
研究概览
简要总结
Graves' orbitopathy (GO) affects about 50% of patients with Graves' disease (GD), and some cannot be cured by current treatments. Orbital fibroblasts involves in the pathogenesis of GO by producing glycosaminoglycans and inflammatory cytokines. Since fibroblast growth factors (FGFs) binding to FGF receptors (FGFRs) can induce proliferation and differentiation of fibroblasts, investigators would like to measure the expression of FGFs and FGFRs in GO patients to see if inhibition of FGF-FGFR pathway has potential in treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosed as thyroid eye disease
- •suggested to accept orbital decompression
排除标准
- •age below 20 or above 80
- •pregnancy
结局指标
主要结局
Serum concentration of selected growth factors
时间窗: 1 year
Investigators would like to measure fibroblast growth factors concentration (ug/mL) by ELISA according to the manufacturers' instruction
次要结局
- RNA expression level of selected growth factor receptors(1 year)
研究者
研究点 (1)
Loading locations...
相似试验
尚未招募
3 期
A Randomized Clinical Trial to Evaluate the Effects of Atorvastatin on Graves' Orbitopathy (GO): the STAGO-2 StudyGraves' OrbitopathyNCT05049603University of Pisa102
已完成
不适用
T and B Cells in Graves' OrbitopathyGraves OphthalmopathyNCT03195296University of Pisa20
尚未招募
2 期
Sirolimus for Graves' Orbitopathy (GO)Graves OphthalmopathyNCT04598815University of Pisa54
已完成
不适用
Sirolimus in Graves' OrbitopathyGraves OphthalmopathyNCT05345119University of Pisa30
已完成
2 期
Effects of Atorvastatin in Graves' Orbitopathy (GO)Thyroid Associated OphthalmopathyHypercholesterolemiaNCT03110848University of Pisa88