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临床试验/NCT05149781
NCT05149781招募中不适用

Standardized Diagnosis and Treatment of Endocrine Hypertension

Affiliated Hospital of Nantong University1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2021年8月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
200
试验地点
1
主要终点
The control rate of blood pressure

研究概览

简要总结

Cases of endocrine hypertension or primary hypertension who have signed informed consent will be collected. Patients with endocrine hypertension will be divided into surgical treatment group and drug treatment group according to actual treatment situation. A database will be established for all patients. The investigators will comprehensively evaluate the general conditions, past medical history, metabolic and biochemical indicators, psychological status, cardiovascular risk factors. All the patients will be followed up for 12 months at baseline, 6 months and 12 months. Clinical data and specimen will be collected.

详细描述

The investigators will collect 100 patients with secretory hypertension and 100 patients with essential hypertension. Patients with endocrine hypertension will be divided into surgical treatment group and drug treatment group according to actual treatment situation. Resected specimens from surgical patients will be used for immunohistochemistry and western blot. A database will be established for all patients to assess their general situation, past medical history, metabolic and biochemical indicators, psychological status, cardiovascular risk factors, etc. The investigators expect to find more accurate screening indicators from blood and urine specimens. All the patients will be followed up for 12 months at baseline, 6 months and 12 months. Blood pressure, degree of atherosclerosis, biochemical markers, hormone levels and cardiac function indicators will be measured at three time points.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • age≥18 years

排除标准

  • myocardial infarction
  • congestive heart failure

结局指标

主要结局

The control rate of blood pressure

时间窗: 12 months

The investigators will compare the proportion of patients with blood pressure below 140/90 mmHg after different treatments.

次要结局

  • Changes of carotid imima-media thickness(12 months)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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