Standardized Diagnosis and Treatment of Endocrine Hypertension

Recruiting

• Conditions: Endocrine Hypertension
• Interventions: Procedure: Standardized diagnosis and treatment

• Registration Number: NCT05149781
• Lead Sponsor: Affiliated Hospital of Nantong University

Brief Summary

Cases of endocrine hypertension or primary hypertension who have signed informed consent will be collected. Patients with endocrine hypertension will be divided into surgical treatment group and drug treatment group according to actual treatment situation. A database will be established for all patients. The investigators will comprehensively evaluate the general conditions, past medical history, metabolic and biochemical indicators, psychological status, cardiovascular risk factors. All the patients will be followed up for 12 months at baseline, 6 months and 12 months. Clinical data and specimen will be collected.

Detailed Description

The investigators will collect 100 patients with secretory hypertension and 100 patients with essential hypertension. Patients with endocrine hypertension will be divided into surgical treatment group and drug treatment group according to actual treatment situation. Resected specimens from surgical patients will be used for immunohistochemistry and western blot. A database will be established for all patients to assess their general situation, past medical history, metabolic and biochemical indicators, psychological status, cardiovascular risk factors, etc. The investigators expect to find more accurate screening indicators from blood and urine specimens. All the patients will be followed up for 12 months at baseline, 6 months and 12 months. Blood pressure, degree of atherosclerosis, biochemical markers, hormone levels and cardiac function indicators will be measured at three time points.

Study Timeline

• Study Start: 2021-08-01
• Study First Submitted: 2021-11-25
• Study First Submitted QC: 2021-11-25
• Study First Posted: 2021-12-08
• Status Verified: 2023-08
• Last Update Submitted: 2023-09-12
• Last Update Posted: 2023-09-13
• Primary Completion: 2024-01-31
• Study Completion: 2024-07-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

age≥18 years

Exclusion Criteria

1. myocardial infarction
2. congestive heart failure
3. stroke

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients with EH	Standardized diagnosis and treatment	patients with endocrine hypertension

Primary Outcome Measures

Name	Time	Method
The control rate of blood pressure	12 months	The investigators will compare the proportion of patients with blood pressure below 140/90 mmHg after different treatments.

Secondary Outcome Measures

Name	Time	Method
Changes of carotid imima-media thickness	12 months	Carotid ultrasound will be used to observe the changes of carotid intima-media thickness after different treatments.

Trial Locations

Locations (1)

Gu Yunjuan; 🇨🇳 Nantong, Jiangsu, China