Changes in Gene Expression and Prognosis of Blood Immune Cells After Cardiopulmonary Bypass Surgery

Recruiting

• Conditions: Acute Kidney Injury
• Interventions: Other: Gene sequencing

• Registration Number: NCT05871203
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

The goal of this observational study is to learn about the changes in gene expression in blood immune cells in after cardiac surgery with cardiopulmonary bypass.The main question it aims to answer is: What specific gene expression changes predict kidney damage after cardiac surgery with cardiopulmonary bypass. Participants received conventional treatment.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-05
• Study First Submitted: 2023-05-15
• Study First Submitted QC: 2023-05-15
• Last Update Submitted: 2023-05-15
• Study Start: 2023-05-17
• Study First Posted: 2023-05-23
• Last Update Posted: 2023-05-23
• Primary Completion: 2023-06-30
• Study Completion: 2023-07-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• 1. Age≥ 18 years old; 2) Cardiopulmonary bypass descending valve replacement (molding), or coronary artery bypass grafting, or macrovascular surgery.

Exclusion Criteria

• 1. any cognitive or mental impairment that is unable to sign the informed consent form; 2) Have basic immune system and blood system diseases; 3) pregnancy; 4) Receiving radiotherapy and chemotherapy before surgery; 5) Receiving immunosuppressive drugs within six months; 6) Have participated in other interventional clinical trials within 30 days before surgery.

Exit Criteria:

1. Incomplete surgery;
2. Secondary transfer in the operating room;
3. Automatically request to terminate the test.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Postoperative acute kidney injury	Gene sequencing	-
Postoperative non-acute kidney injury	Gene sequencing	-

Primary Outcome Measures

Name	Time	Method
Postoperative acute kidney injury	Within 48 hours after surgery	SCr was elevated ≥ 26.5 micromol/L or 1.5 times the baseline for SCr ≥ or urine output \< 0.5 mL/kg/hour within 6 hours within 48 hours

Trial Locations

Locations (1)

The Second Affiliated Hospital of Zhejiang University anesthesiology department; 🇨🇳 Hangzhou, Zhejiang, China