NL-OMON38861
Completed
Not Applicable
PET imaging of neuroinflammation in treatment resistant major depressive disorder - TRD-inflammation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Depression
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 60
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Age above 18 and below 50 years
- •\- Written informed consent for participation
- •\- Diagnosis of MDD as ascertained by structured Clinical Interview for DSM\-IV (SCID\-I) or MiniScan.
- •\- HDRS\-17 \>20
- •\- High level of treatment resistance/refractoriness (Ruhe et al. 2012\) as defined by non\-response (\<50% decrease in symptoms) after \>3 classes of antidepressants, given for at least 4 weeks at at least minimal effective dosages. The last antidepressant may be continued during the study.;Healthy controls
- •\- Age above 18 and below 50 years
- •\- Written informed consent for participation
Exclusion Criteria
- •\- The use of benzodiazepines within 1 week prior to the PET\-scan (benzodiazepines with half\-lives \>24hrs must be stopped \>5 times this half live before the PET\-scan).
- •\- The use of anticoagulants or having coagulation disorder.
- •\- Use of somatic medication that may affect the immune system (e.g. corticoids, anti\-inflammatory drugs, immune suppressive drugs)
- •\- Use of any investigational drug
- •\- Current or recent (\<1 year) alcohol or substance abuse
- •\- Current or recent (\<4 weeks) infectious or inflammatory disease
- •\- Current systemic disease
- •\- Somatic, organic or neurological disorder
- •\- Claustrophobia
- •\- Presence of materials in the body that can be magnetized, like a pacemaker, metal fragments, shunts, artificial heart valves, vascular clips, fixed hearing aid, tattoos containing metal, hair implants and artificial dentures.;Healty controls
Outcomes
Primary Outcomes
Not specified
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