Enhancing extinction of conditioned sexual response by a partial NMDA receptors agonist.

Completed

• Conditions: Sexual Motivation Disorders; Hyposexuality; Seksuele aandoeningen; Hypersexuality

• Registration Number: NL-OMON41206
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 68

Inclusion Criteria

- Age < 18 or > 45 years
- Heterosexual orientation

Exclusion Criteria

- Pregnancy or lactation
- Colour blindness
- A diagnosis of affective, psychotic or substance related disorder according to DSM 5.
- Current or recurrent use (less than 4 weeks before participation) of medication that may affect sexual response. To determine possible sexual side-effects the *Farmacotherapeutisch kompas* 2014 will be used.
- Current or previous disorders of the genitals or treatments for such disorders that may influence the sexual response or the measurement of the response.
- Other medical disorders that may influence the sexual response or the measurement of the response.
- Current or recurrent use (less than 4 weeks before participation) of medication that may affect or interact with the effects of DCS. To determine possible contra-indications, instructions for use as supplied by *King Pharmaceuticals* will be used (see Appendix).
- Current or previous disorders (like severe anxiety or psychosis, liver disease or severe renal insufficiency, epilepsy) that increase the possibility of side effects of DCS and for which usage of DCS is contra-indicated.
- Alcohol or drug use on the night and day before participation, as well as alcohol and drug use between test moments (day 1 and day 2).

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) measures of vaginal pulse amplitude (VPA) assessed by a vaginal<br /><br>photoplethysmograph; 2) Subjective ratings of US expectancy, affective valence<br /><br>and sexual arousal</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nvt</p><br>