C1q/TNF-related Proteins in Non-Alcoholic Fatty Liver Disease

• Conditions: NAFLD

• Registration Number: NCT02083159
• Lead Sponsor: Korea University

Brief Summary

Non-alcoholic fatty liver disease (NAFLD) is characterized by an accumulation of fat in the liver, which is one of the most common forms of chronic liver disease in developed countries. In western countries, the prevalence of NAFLD in the general population is estimated to be 20-30%; in obese populations, this increases to 57.5-74%. But, it hasn't been clearly elucidated yet regarding the underlying disease pathophysiology and treatmet strategy.

Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in glucose metabolism and inflammation.

The investigators tried to clarify the relationship between CTRP family and NAFLD in Korean men and women.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2014-03-07
• Study First Submitted QC: 2014-03-07
• Study First Posted: 2014-03-11
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-19
• Last Update Posted: 2016-09-21
• Primary Completion: 2016-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• 20<age<80
• apparently healthy subjects

Exclusion Criteria

• a history of CVD
• diabetes
• stage 2 hypertension
• malignancy
• severe renal or hepatic disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
serum concentration of CTRP-1, 3, or 9 in the subjects with/without NAFLD	at enrollment

Secondary Outcome Measures

Name	Time	Method
The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles	at enrollment

Trial Locations

Locations (1)

Korea Univ. Guro Hospital; 🇰🇷 Seoul, Korea, Republic of