C1q/TNF-related Proteins in Non-Alcoholic Fatty Liver Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- serum concentration of CTRP-1, 3, or 9 in the subjects with/without NAFLD
研究概览
简要总结
Non-alcoholic fatty liver disease (NAFLD) is characterized by an accumulation of fat in the liver, which is one of the most common forms of chronic liver disease in developed countries. In western countries, the prevalence of NAFLD in the general population is estimated to be 20-30%; in obese populations, this increases to 57.5-74%. But, it hasn't been clearly elucidated yet regarding the underlying disease pathophysiology and treatmet strategy.
Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in glucose metabolism and inflammation.
The investigators tried to clarify the relationship between CTRP family and NAFLD in Korean men and women.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •20<age<80
- •apparently healthy subjects
排除标准
- •a history of CVD
- •stage 2 hypertension
- •malignancy
- •severe renal or hepatic disease
结局指标
主要结局
serum concentration of CTRP-1, 3, or 9 in the subjects with/without NAFLD
时间窗: at enrollment
次要结局
- The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles(at enrollment)