Hepatitis E Infection : Emergence Mechanisms in North-Eastern France of Polymorphic Clinical Forms.
- Conditions
- Hepatitis E Infection in Humans and in Environment
- Interventions
- Other: Only advice for diagnosis and prevention
- Registration Number
- NCT03524014
- Lead Sponsor
- Central Hospital, Nancy, France
- Brief Summary
The present research aims to collect virological and clinical data on hepatitis E virus (HEV) infections, either in acute or chronic forms of HEV infection in North-Eastern France, with liver- or non liver-related symptoms, plus data on HEV circulation in the outside environment. The purpose of this study is to improve the diagnosis and care of HEV-infected patients, as well as the preventive features to take into account in order to avoid food- and environment-borne infections. At last, we will investigate HEV molecular characteristics, with the hypothesis that some advantageous HEV strains coul be more pathogenic for some tissues and/or organs.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 40
- HEV-infected patients, with hepatitis and/or neurological and/or renal symptoms
- Patients, with hepatitis and/or neurological and/or renal symptoms, infected by other viruses leading to hepatitis (hepatitis B, hepatitis C, hepatitis A ...)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description HEV-infected patients with hepatitis Only advice for diagnosis and prevention - HEV-infected patients with neurological features Only advice for diagnosis and prevention - HEV-infected patients with kidney features Only advice for diagnosis and prevention -
- Primary Outcome Measures
Name Time Method HEV RNA (quantitative PCR assay) 2 years Guidelines to improve HEV detection by using the 2 virological assays
Anti-HEV IgM (qualitative assay); 2 years Guidelines to improve HEV detection by using the 2 virological assays
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Schvoerer
🇫🇷Vandoeuvre Les Nancy, France