A Randomized Clinical Trial on the Use of Early Intermittent Non-Invasive Ventilation in Patients Suffering From Acute Lung Injury After Allogeneic Transplantation
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 86
研究概览
简要总结
Acute lung injury (ALI) is an early complication after allogeneic transplantation causing significant mortality and morbidity. Little is known on early markers and treatment of this complication. Recent data (Hilbert et al.) suggested a beneficial effect of Non-Invasive-Ventilation in ALI-patients immunosuppressed because a many different reasons including stem-cell transplantation.
The investigators study is designed to evaluate early markers of ALI after allogeneic transplantation. In case ALI is documented patients are randomized to either conventional therapy (oxygen-support) or conventional therapy plus intermittent Non-Invasive Ventilation. The hypothesis is that Non-Invasive Ventilation improves outcome of ALI after allogeneic transplantation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing allogeneic transplantation presenting with at least two of the following criteria
- •Respiratory rate >25 / min
- •Oxygenation Index <300
- •Continuous oxygen-saturation <92% whilst breathing room air
排除标准
- •Indication for Emergency intubation
- •Hemodynamic instability
- •Left ventricular failure
- •No consent
研究组 & 干预措施
Oxygen
Conventional Treatment including Oxygen-support
NIV
Conventional Treatment plus intermittent Non-Invasive-Ventilation
干预措施: Intermittent Non-Invasive Ventilation (Other)