Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment
- Conditions
- Acute Lung Injury
- Interventions
- Other: Intermittent Non-Invasive Ventilation
- Registration Number
- NCT00852605
- Lead Sponsor
- Technische Universität Dresden
- Brief Summary
Acute lung injury (ALI) is an early complication after allogeneic transplantation causing significant mortality and morbidity. Little is known on early markers and treatment of this complication. Recent data (Hilbert et al.) suggested a beneficial effect of Non-Invasive-Ventilation in ALI-patients immunosuppressed because a many different reasons including stem-cell transplantation.
The investigators study is designed to evaluate early markers of ALI after allogeneic transplantation. In case ALI is documented patients are randomized to either conventional therapy (oxygen-support) or conventional therapy plus intermittent Non-Invasive Ventilation. The hypothesis is that Non-Invasive Ventilation improves outcome of ALI after allogeneic transplantation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 86
patients undergoing allogeneic transplantation presenting with at least two of the following criteria
- Respiratory rate >25 / min
- Oxygenation Index <300
- Continuous oxygen-saturation <92% whilst breathing room air
- Indication for Emergency intubation
- Hemodynamic instability
- Left ventricular failure
- GCS <8
- No consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description NIV Intermittent Non-Invasive Ventilation Conventional Treatment plus intermittent Non-Invasive-Ventilation
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method