The effects of fetal fibroblast in skin wound healing

Phase 1

Conditions: Skin Wound.
Open wound of unspecified body region

Registration Number: IRCT201302218177N6

Lead Sponsor: Vice chancellor for research of Tehran University of Medical

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 10

Inclusion Criteria

Laboratory inclusion criteria:
1. Pregnant women who are older than 18 years old that had to be aborted
2. Filling informed consent
3. Aborted fetus with the age of 11 to 14 weeks
4.Lack of infectious diseases (HIV-HBV-HCV)
5.Lack consumption of immune-suppressive and cytotoxic drugs during past 6 months

Laboratory exclusion criteria:
1. Aborted fetus that is younger than 11 weeks or older than 14 weeks
2.Pregnant women who are younger than 18 years old

Clinical inclusion criteria:
1.Patients with the age of 20 to 60 years old
2. Those who need skin graft surgery
3.The extent of surgical site wound 10-30%
4. Filling informed consent
5. Lack of co-morbidity

Clinical exclusion criteria:
1.Under the age of 20 years and above 60 years
2.The extent of surgical site wound more than 30% and less than 10%
3.Lack of informed consent

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Wound healing. Timepoint: Examination and photography on 3, 5, 7, 11, 13 and 15 days and 1 month after surgery - biopsy on 7 day? after surgery. Method of measurement: Observation and Examination and Biopsy.

Secondary Outcome Measures

Name	Time	Method
Pain. Timepoint: Three, five, seven, nine, eleven, thirteen and fifteen days after surgery. Method of measurement: Visual Analogue Scale.;Infection. Timepoint: Seven and fifteen days after surgery. Method of measurement: Examination, Wound Culture.;Scar. Timepoint: Three and six months after surgery. Method of measurement: Vancouver Scar Scale.