Evaluation of the exosome effect of Wharton jelly mesenchymal stem cells in the treatment of dry eye
- Conditions
- Dry eye due to Sjogren's syndrome.Sicca syndrome [Sjogren]M35.0
- Registration Number
- IRCT20211102052948N1
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 5
Middle-aged women between the ages of 45 and 35 with dry eye
Clinically and serologically diagnosed by an ophthalmologist, rheumatologist or internal medicine specialist with sjogren’s syndrome.
Previous use of artificial tears can not relieve it.
Symptoms of dry eye in at least one patient's eye include redness, dryness, burning sensation, foreign body sensation, eye discomfort, or visual fatigue.
Tear discharge test (Schermer test) both eyes = 10 mm / 5 min
Tear break time (TBUT) will be less than 10 seconds.
People who are allergic to any drug .
Pregnant or lactating women .
Patients with active fungal, bacterial or viral keratitis or conjunctivitis.
People with serious heart, lung, liver or kidney disease or other incurable eye diseases such as glaucoma, uveitis.
People who wear contact lenses and do not want to remove them in the study.
Perform eye surgery (including cataract surgery) in the last three months.
Simultaneous enrollment in other interventional clinical trials.
Use of eye drops in the last 24 hours that may affect the clinical study.
They have serious systemic diseases.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ocular Surface Disease Index (OSDI) Score. Timepoint: Before the intervention and in the Time Frame: 1 week, 2 weeks, 3 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks, 12 weeks after the intervention. Method of measurement: A valid questionnaire is 12 questions that will be used to measure the symptoms of dry eye.
- Secondary Outcome Measures
Name Time Method