The effect of intravenous corticosteroid and periarticular corticosteroid injection on the post-operative knee function in total knee replacement patient; a prospective randomize control trial
Phase 4
Recruiting
- Conditions
- qaudriceps muscle power recovery, walking time, visual analog pain scale and functional knee score after total knee replaementperiarticular corticosteroid, intravenous corticosteroid,total knee replacement, quadriceps muscle power,pain
- Registration Number
- TCTR20240419006
- Lead Sponsor
- Faculty of medicine, Ramathibodi Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
1. end-stage OA knee
2. preoperative quadriceps muscle at least grade 4
3. preoperative independent walking ability
Exclusion Criteria
1. revision knee surgery
2. needed metal augmentation
3. contra indication to NSAID
4. contra indication to corticosteroids
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method quadriceps muscle power preop, post op Day3, 2 week, 6 week, 3 month hand held dynamometer
- Secondary Outcome Measures
Name Time Method ESR preop, post op day1, day3, 2 week serology,CRP preop, post op day1, day3, 2 week serology,Visual analog pain scale preop, day 3, 2 week, 6 weeks, 3 month patient report pain scale,WOMAC knee score preop, 6 week, 3 month questionnaire ,knee society score preop, 6 week, 3 month physical examination and questionnaire ,morphine consumption peri-operative period, in admission amount of morphine request during admission,POC glucose preop, post-op day1-day2-day3 and 2 week blood examination,nausea and vomit peri-operative period, in admission amount of ondansetron request during admission,wound complication day3 , 2week and 3 month wound discharge, wound dehiscence, surgical site infection ,time up and go test preop, day 3, 2 week, 6 week, 3 month second