NCT06071377招募中不适用
Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)
National Alliance for Sickle Cell Centers10 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2023年4月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 10
- 主要终点
- Hemoglobin variant quantification
研究概览
简要总结
The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Are willing to voluntarily participate and sign the study consent
- •Know/suspect they have SCT and are willing to get tested to confirm/learn about their SCT status
- •Adults ages 18 and older
排除标准
- •Unwilling to sign consent
- •Known end-stage renal disease or dialysis
- •Known SCD (including sickle cell-beta thalassemia)
- •People who do not have SCT
结局指标
主要结局
Hemoglobin variant quantification
时间窗: Through study completion, an average of 2 years
Determine range of variability in baseline %HbS in SCT subjects and relationship of baseline %HbS to markers of hemolysis (LDH, reticulocytes, haptoglobin), coagulopathy (D-dimer), and renal disease (urine albumin/creatinine ratio)
次要结局
- Red blood cell rheology(Through study completion, an average of 2 years)
- Natural History(Through study completion, an average of 2 years)
研究者
研究点 (10)
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