'Eat Smart for Success': Investigating the use of pharmacotherapy in adolescents for weight loss maintenance: The role of appetite

Completed

• Conditions: Obesity; Adolescent Obesity; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN08063839
• Lead Sponsor: Royal Children's Hospital (Australia)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-11-05
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

1. 12-18 years
2. BMI >95th centile for age and gender
3. Pubertal stage =3
4. Ability for parent and child to read and understand written instructions in English; parents able to give informed written consent in English; adolescent able to give verbal assent
5. Successfully completed a 6 month lifestyle intervention without a gain in BMI z-score

Exclusion Criteria

1. Those with renal disorders, diabetes, diagnosed psychological disorders
2. Those taking stimulants or psychotropic medication or drugs known to alter metabolism including insulin sensitisers, glucocorticoids, thyroxine, other weight loss medications
3. Those taking any drugs known to be contraindicated with metformin therapy
4. Known adverse reactions to metformin
5. Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
BMI (pre and post intervention)