Effect of a single preoperative glucocorticosteroid injection on inflammatory response following thryoidectomy
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Patients undergoing surgery for thyroid disease.
- Registration Number
- CTRI/2018/03/012419
- Lead Sponsor
- Jawaharlal Nehru Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Patients with symptomatic thyroid disease who were candidates for thyroidectomy
Exclusion Criteria
Patients having any of the following:
1.American Society of Anesthesiologists
(ASA) physical class III or IV.
2.Age more than 75 years.
3.Pregnancy.
4.Intake of corticosteroids within
past 4 weeks
5.Coagulation disorders.
6.Cushing disease.
7.Uncontrolled diabetes mellitus.
8.Severe hepatic impairment.
9.Renal impairment.
10.Systemic Tuberculosis.
11.Osteoporosis.
12.Immunocompromised states.
13.Pre- existing wide angle glaucoma
14.Severe systemic bacterial, viral or
fungal infections.
15.Patients with preoperative deranged
cell counts, C reactive protein levels
or cytokine profile
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Peri-operative changes in: <br/ ><br> <br/ ><br>1.Levels of pro-inflammatory cytokines (TNFα, IL-1β and IL-6) and anti-inflammatory cytokine (IL-10) <br/ ><br> <br/ ><br>2.Leukocyte count <br/ ><br> <br/ ><br>3.C-Reactive ProteinTimepoint: At 6 hours and 24 hours post thyroidectomy
- Secondary Outcome Measures
Name Time Method ILTimepoint: N/A