Characteristic of Patients With Gastroesophageal Varices and Portal Cavernoma
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- History of variceal bleeding
研究概览
简要总结
Myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, may lead to gastroesophageal varices. The quality of life, morbidity, and mortality of MPN patients mainly depend on disease-related symptoms, thromboembolic and hemorrhagic complications. Previous studies have shown that JAK2 V617F has a prominent role in vascular risk and MPN-associated gastroesophageal varices. Portal vein thrombosis and portal cavernoma frequently occur in the MPN population and the management of gastroesophageal varices in these patients are sometimes technically difficult. The aim of this study is to investigate the the characteristics of patients with gastroesophageal varices and portal caver cavernoma with or without JAK2 mutation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •male or female patients aged 18-75
- •diagnosed as portal hypertension and portal cavernoma by contrast-enhanced computed tomography
- •underwent JAK2 mutation test
排除标准
- •combined known etiologies of chronic liver disease, including hepatitis, primary biliary cirrhosis, schistosomiasis, and non-alcoholic fatty liver disease.
- •other factors judged by the investigator that may affect the safety of the subject or the compliance of the trial. Such as serious illnesses (including mental illness) that require combined treatment, serious laboratory abnormalities, or other family or social factors.
结局指标
主要结局
History of variceal bleeding
时间窗: 1 day (the same time as diagnosis)
Have a history of the occurrence of gastroesophageal variceal bleeding
次要结局
- 1-year death rate(1 year)
- Complications of portal hypertension(1 year)
研究者
XiaoquanHUANG
Resident
Shanghai Zhongshan Hospital