CT Radiomic Features of Pancreatic Neuroendocrine Neoplasms
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 2
- 主要终点
- Interobserver variability in delineating panNENs on CT
研究概览
简要总结
The aim of this study is to quantify inter-observer variability in delineating pancreatic neuroendocrine neoplasm (PanNEN) on Computerized Tomography (CT) images and its impact on radiomic features (RF), subsequently to this determination, to use CT texture analysis to predict, histological characteristics of PanNEN on CT scans.
详细描述
CT imaging is the most widely used modality for studying radiomic features due to its ability to assess tissue density, shape, texture and size before, during and after therapy. To the best of the investigator's knowledge, the impact of inter-observer delineation variability on the reliability of CT RF for PanNEN patients, including Hounsfield unit (HU) values-, shape-, and texture-based features, has not yet been assessed. One this has been determined, an additional evaluation will be conducted to correlate the morphologically observed images with their histopathological characteristics.
The ultimate potential objective of this research is to identify and predict characteristics of aggressiveness of PanNEN in CT scans.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •> 18 years of age
- •pancreatic neuroendocrine neoplasm with intervention and biopsy
- •availability of pre-operatory CT scan with or without IV contrast agent- inInstitution from 2009-2017
排除标准
- •pregnant women
结局指标
主要结局
Interobserver variability in delineating panNENs on CT
时间窗: 6 months
Asses inter-observer variability on CT- scans (with contrast alone)
次要结局
- Use CT texture analysis to predict, histological characteristics of PanNEN on CT scans(6 months)
研究者
Francesco De Cobelli
Professor of Radiology, Head of Clinical and Experimental Radiology
IRCCS San Raffaele