Clinical Study on Metabolic Typing of Gastric Cancer Based on Transcriptome, Metabolome and Other Multi-omics
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 480
- 试验地点
- 1
- 主要终点
- The differences of the metabolism information
研究概览
简要总结
In the study, the investigators obtained gastric cancer tissues from 480 gastric cancer patients who had undergone surgery at the Zhejiang Cancer Hospital's biospecimen bank between 2012-2019, and obtained relevant clinical information. The gastric cancer tissues were subjected to transcriptomic, metabolomic and other multi-omics testing, and analyzed for the metabolic changes of gastric cancer, and proposed to discover relevant therapeutic targets.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18≤age≤80
- •Histologically or cytologically confirmed gastric cancer
- •Undergo surgery for radical or palliative gastric cancer (both open and laparoscopic)
- •Patients with survival follow-up information
排除标准
- •Two or more kinds of malignant tumors at the same time
- •Incomplete or missing case information
- •Preoperative diagnosis of residual gastric cancer
结局指标
主要结局
The differences of the metabolism information
时间窗: through study completion, an average of 6 months
The differences of the metabolism information between gastric cancer tissues and non-cancerous gastric cancer tissues. These data included Metabolizing enzyme mRNA expression and metabolite content.
次要结局
未报告次要终点
研究者
Xiangdong Cheng
Secretary of the party committee
Zhejiang Cancer Hospital