on Invasive Ventilation in COPD: Predicting outcome in hospital and assessing quality of life over one year

Not Applicable

Completed

• Conditions: Chronic obstructive pulmonary disease (COPD); Respiratory

• Registration Number: ISRCTN22921168
• Lead Sponsor: orthumbria Healthcare NHS Foundation Trust

Brief Summary

2020 Abstract results in https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2020.201.1_MeetingAbstracts.A4584?fbclid=IwAR3vfUdKww1qxJXR9rcuq1QowgmmP-ofFbcoD3_AJZ3JKYZxGk-ey4xWwmg#aff3 results presented at American Thoracic Society International Conference (added 12/05/2020) 2019 Abstract results in http://dx.doi.org/10.1136/thorax-2019-BTSabstracts2019.63 results presented at British Thoracic Society Winter Meeting (added 12/05/2020) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33479109/ (added 11/01/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-07-04
• Study Completion: 2020-11-30
• Last Update Posted: 29 August 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 844

Inclusion Criteria

1. Age 35 years or older
2. Smoking history greater than or equal to 10 pack years (1 pack per day for 10 years)
3. Obstructive spirometry (FEV1/FVC < 0.7)
4. Acute exacerbation of COPD (AECOPD) primary diagnosis
5. Respiratory acidosis treated with NIV or IPPV (arterial blood gas pH <7.35, pCO2 > 6.5)

Exclusion Criteria

1. Previous inclusion in the study
2. Other illness likely to limit survival to less than 1 year

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Prediction of in-hospital mortality within the validation cohort assessed by the area under the receiver operating characteristic (AUROC) curve for tools developed using:<br> 1. Indices available on admission<br> 2. All indices up to and including the time of deterioration<br>