ISRCTN50562632
Completed
Not Applicable
Prospective and randomised multicentre trial investigating the pros and cons of different extent of mesial resection in surgery for mesial temporal lobe epilepsy
German Research Council (Deutsche Forschungsgemeinschaft [DFG]) (Germany)0 sites250 target enrollmentAugust 21, 2008
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intractable mesial temporal lobe epilepsy (MTLE)
- Sponsor
- German Research Council (Deutsche Forschungsgemeinschaft [DFG]) (Germany)
- Enrollment
- 250
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Patients suffering from intractable temporal lobe epilepsy
- •2\. Drug resistance: seizure history lasting more than two years
- •3\. Pre\-surgical evaluation led to the recommendation of either a partial temporal lobe resection combined with amygdalohippocampectomy or a more restricted selected selective amygdalohippocampectomy (SAH)
- •4\. Only cases with mesial involvement were included
- •5\. Patients had to be at least 18 years old (either sex) and able to understand the study plan
- •6\. Written informed consent
Exclusion Criteria
- •1\. Previous temporal lobe surgery
- •2\. Inability to do undergo neuropsychological testing because of retardation or foreign language
- •3\. Mesial resection restricted to uncus and amygdala
- •4\. No usable pre\-operative magnetic resonance imaging (MRI) for volumetrical analyses
- •5\. Pathology not allowing for randomisation (far dorsal reaching resection necessary)
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
A prospective randomised, multicentre trial to assess the impact of laboratory based rapid diagnosis on outcome in patients with Blood Stream InfectionsTopic: InfectionSubtopic: Infection (all Subtopics)Disease: Infectious diseases and microbiologyInfections and InfestationsISRCTN97107018orth Bristol NHS Trust (UK)4,536
Completed
Not Applicable
A prospective, multi-centre, randomised trial comparing low-dose aspirin with low-dose aspirin plus low-intensity oral anticoagulation in the primary prevention of thrombosis in patients positive for antiphospholipid antibodiesPrevention of thrombosisCirculatory SystemThrombosisISRCTN81818945Arthritis Research Campaign (ARC) (UK)
Completed
Not Applicable
Prospective, randomised, multicentre trial to assess short- and long-term results after laparoscopic and conventional resection of colorectal carcinomaISRCTN18106465Charité - University Medicine Berlin (Germany)1,200
Completed
Not Applicable
Prospectively randomised multicenter trial on the influence on mesh exposure rates of partially absorbable transobturatoric mesh after surgery for pelvic organ prolapse in the anterior compartmentN81.1N81.2CystoceleIncomplete uterovaginal prolapseDRKS00004566Diakoniekrankenhaus200
Completed
Not Applicable
You've got family: the add-on effects of family involvement in cognitive behavioural therapy in substance dependent patientsAddiction, substance abuseMental and Behavioural DisordersMental and behavioural disorders due to multiple drug use and use of other psychoactive substancesISRCTN47318778Radboud University Nijmegen (Netherlands)144