Effect of Individualized Exercise in Elderly Patients With Coronary Heart Disease
- Conditions
- Coronary Heart Disease
- Interventions
- Drug: optimal medical therapy ：aspirin, clopidogrel, statins.Behavioral: Individual rehabilitation exercise training
- Registration Number
- NCT06588231
- Brief Summary
The benefits of cardiac rehabilitation have been supported by a large amount of evidence-based medicine. Cardiac rehabilitation can correct cardiovascular risk factors, reduce morbidity and mortality, and improve quality of life.
- Detailed Description
Cardiac rehabilitation includes drug, exercise, nutrition, psychological and behavioral intervention, smoking and alcohol restriction five prescription comprehensive medical measures, so as to improve the symptoms and prognosis of patients. Cardiac rehabilitation can not only delay the progress of the disease and improve the prognosis, but also improve the physical and mental state of patients, which has been recommended by the European Cardiology Association, the American Heart Association and the American Heart Association as Class I in the treatment of cardiovascular disease. Through the comprehensive intervention of patients, their physical, psychological and social functions can be restored to the best state, which can prolong life and significantly improve the quality of life, which is the essence of modern cardiac rehabilitation. Exercise rehabilitation is the core content of cardiac rehabilitation, which refers to the use of appropriate body exercise to help patients promote physical and mental health through exercise prescription and exercise guidance on the basis of comprehensive evaluation. The realization of sports rehabilitation requires a reasonable exercise prescription, which refers to the method of prescribing patients' exercise content and amount of exercise in the form of prescription according to individual physical condition and combining with environment and preference as far as possible. The best exercise prescription should be able to comprehensively promote health-related physical fitness, that is, cardiopulmonary endurance, muscle strength and endurance, flexibility, body composition and neuromotor fitness, and should be formulated in accordance with the principles of FITTVP, including frequency (several times a week), intensity (exertion), time (duration or total time), mode (pattern or type), as well as total and progress.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 200
- Coronary heart disease: coronary angiography confirmed patients with coronary heart disease.
- Age is 60-75 years old, and the clinical sinus rhythm is stable.
- Left ventricular ejection fraction was> 40%.
- Informed consent and voluntary participation.
- Patients with severe organic cardiac and lung diseases.
- Patients with hemiplegia and other physical action disorders.
- A history of mental illness.
- Uncontrolled hypertension, and hemodynamic instability.
- Severe nephropathy and severe peripheral artery disease.
- Patients with bone and joint diseases who are not suitable for exercise.
- Uncontrolled endocrine system and other diseases.
- Antibiotics and anti-diarrheal medications have not been used for at least 3 months.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description the control group optimal medical therapy ：aspirin, clopidogrel, statins. The patients in the control group were treated with routine rehabilitation nursing, while those in the control group were treated with routine antiplatelet drugs and lipid-lowering drugs after operation. Professional salesmen, according to the specific physical conditions of the patients, formulate corresponding recipes to ensure that the patients have a light diet, low salt, low fat and high nutritional value, and prohibit tobacco and alcohol. the exercise group Individual rehabilitation exercise training The exercise group was given individualized rehabilitation training intervention on the basis of the control group. After 2 weeks of adaptive exercise training, there were no adverse events and voluntarily continued the participants. Under the guidance of the specialist, the exercise group received moderate and high intensity interval training, 3 times a week, 30-40 minutes each time, including the beginning of 5 minutes of warm-up and the last 5 minutes of cooling-off period. the exercise group optimal medical therapy ：aspirin, clopidogrel, statins. The exercise group was given individualized rehabilitation training intervention on the basis of the control group. After 2 weeks of adaptive exercise training, there were no adverse events and voluntarily continued the participants. Under the guidance of the specialist, the exercise group received moderate and high intensity interval training, 3 times a week, 30-40 minutes each time, including the beginning of 5 minutes of warm-up and the last 5 minutes of cooling-off period.
- Primary Outcome Measures
Name Time Method Gut microbiome one year Fecal DNA isolation was performed using the QIA amp Fast DNA Stool Mini Kit (Qiagen, cat. 51604). After DNA extraction, fecal DNA was used for library preparation, and whole-genome shotgun sequencing was performed on the Illumina NovaSeq-6000 plat- form. From the raw metagenomic sequencing data, low-quality reads were discarded by the sequencing facility and reads belonging to human contaminations were removed by mapping the data to the reference genomes using Bowtie2. After filtering, on average, 54.8 million paired reads per sample were obtained for subsequent analysis.
Plasma metabolites profiles one year Microbial metabolites profiles were generated using MetaPhlAn4 (version 4.0.3).
6MWT one year 6-minute walk test
LDL one year low density lipoprotein
VO2peak one year peak oxygen uptake
- Secondary Outcome Measures
Name Time Method Plasma metabolites concentration one year The untargeted metabolome analysis was performed using an LC-MS/MS system.
Trial Locations
- Locations (1)
the First Affiliated Hospital of Nanjing Medical University
🇨🇳Nanjing, Jiangsu, China